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c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation

The c-Jun NH(2)-terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathway depends on the cell type. Here we examined the role of JNK1 and JNK2 in CD8(+) T cells. Unlike CD4(+) T ce...

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Autores principales: Conze, Dietrich, Krahl, Troy, Kennedy, Norman, Weiss, Linda, Lumsden, Joanne, Hess, Patricia, Flavell, Richard A., Le Gros, Graham, Davis, Roger J., Rincón, Mercedes
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193724/
https://www.ncbi.nlm.nih.gov/pubmed/11927626
http://dx.doi.org/10.1084/jem.20011508
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author Conze, Dietrich
Krahl, Troy
Kennedy, Norman
Weiss, Linda
Lumsden, Joanne
Hess, Patricia
Flavell, Richard A.
Le Gros, Graham
Davis, Roger J.
Rincón, Mercedes
author_facet Conze, Dietrich
Krahl, Troy
Kennedy, Norman
Weiss, Linda
Lumsden, Joanne
Hess, Patricia
Flavell, Richard A.
Le Gros, Graham
Davis, Roger J.
Rincón, Mercedes
author_sort Conze, Dietrich
collection PubMed
description The c-Jun NH(2)-terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathway depends on the cell type. Here we examined the role of JNK1 and JNK2 in CD8(+) T cells. Unlike CD4(+) T cells, the absence of JNK2 causes increased interleukin (IL)-2 production and proliferation of CD8(+) T cells. In contrast, JNK1-deficient CD8(+) T cells are unable to undergo antigen-stimulated expansion in vitro, even in the presence of exogenous IL-2. The hypoproliferation of these cells is associated with impaired IL-2 receptor α chain (CD25) gene and cell surface expression. The reduced level of nuclear activating protein 1 (AP-1) complexes in activated JNK1-deficient CD8(+) T cells can account for the impaired IL-2 receptor α chain gene expression. Thus, JNK1 and JNK2 play different roles during CD8(+) T cell activation and these roles differ from those in CD4(+) T cells.
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spelling pubmed-21937242008-04-14 c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation Conze, Dietrich Krahl, Troy Kennedy, Norman Weiss, Linda Lumsden, Joanne Hess, Patricia Flavell, Richard A. Le Gros, Graham Davis, Roger J. Rincón, Mercedes J Exp Med Original Article The c-Jun NH(2)-terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathway depends on the cell type. Here we examined the role of JNK1 and JNK2 in CD8(+) T cells. Unlike CD4(+) T cells, the absence of JNK2 causes increased interleukin (IL)-2 production and proliferation of CD8(+) T cells. In contrast, JNK1-deficient CD8(+) T cells are unable to undergo antigen-stimulated expansion in vitro, even in the presence of exogenous IL-2. The hypoproliferation of these cells is associated with impaired IL-2 receptor α chain (CD25) gene and cell surface expression. The reduced level of nuclear activating protein 1 (AP-1) complexes in activated JNK1-deficient CD8(+) T cells can account for the impaired IL-2 receptor α chain gene expression. Thus, JNK1 and JNK2 play different roles during CD8(+) T cell activation and these roles differ from those in CD4(+) T cells. The Rockefeller University Press 2002-04-01 /pmc/articles/PMC2193724/ /pubmed/11927626 http://dx.doi.org/10.1084/jem.20011508 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original Article
Conze, Dietrich
Krahl, Troy
Kennedy, Norman
Weiss, Linda
Lumsden, Joanne
Hess, Patricia
Flavell, Richard A.
Le Gros, Graham
Davis, Roger J.
Rincón, Mercedes
c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
title c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
title_full c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
title_fullStr c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
title_full_unstemmed c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
title_short c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
title_sort c-jun nh(2)-terminal kinase (jnk)1 and jnk2 have distinct roles in cd8(+) t cell activation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193724/
https://www.ncbi.nlm.nih.gov/pubmed/11927626
http://dx.doi.org/10.1084/jem.20011508
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