Cargando…

B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen

Splenectomized individuals are prone to overwhelming infections with encapsulated bacteria and splenectomy of mice increases susceptibility to streptococcal infections, yet the exact mechanism by which the spleen protects against such infections is unknown. Using congenitally asplenic mice as a mode...

Descripción completa

Detalles Bibliográficos
Autores principales: Wardemann, Hedda, Boehm, Thomas, Dear, Neil, Carsetti, Rita
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193734/
https://www.ncbi.nlm.nih.gov/pubmed/11901202
http://dx.doi.org/10.1084/jem.20011140
_version_ 1782147539754024960
author Wardemann, Hedda
Boehm, Thomas
Dear, Neil
Carsetti, Rita
author_facet Wardemann, Hedda
Boehm, Thomas
Dear, Neil
Carsetti, Rita
author_sort Wardemann, Hedda
collection PubMed
description Splenectomized individuals are prone to overwhelming infections with encapsulated bacteria and splenectomy of mice increases susceptibility to streptococcal infections, yet the exact mechanism by which the spleen protects against such infections is unknown. Using congenitally asplenic mice as a model, we show that the spleen is essential for the generation of B-1a cells, a B cell population that cooperates with the innate immune system to control early bacterial and viral growth. Splenectomy of wild-type mice further demonstrated that the spleen is also important for the survival of B-1a cells. Transfer experiments demonstrate that lack of these cells, as opposed to the absence of the spleen per se, is associated with an inability to mount a rapid immune response against streptococcal polysaccharides. Thus, absence of the spleen and the associated increased susceptibility to streptococcal infections is correlated with lack of B-1a B cells. These findings reveal a hitherto unknown role of the spleen in generating and maintaining the B-1a B cell pool.
format Text
id pubmed-2193734
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21937342008-04-14 B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen Wardemann, Hedda Boehm, Thomas Dear, Neil Carsetti, Rita J Exp Med Original Article Splenectomized individuals are prone to overwhelming infections with encapsulated bacteria and splenectomy of mice increases susceptibility to streptococcal infections, yet the exact mechanism by which the spleen protects against such infections is unknown. Using congenitally asplenic mice as a model, we show that the spleen is essential for the generation of B-1a cells, a B cell population that cooperates with the innate immune system to control early bacterial and viral growth. Splenectomy of wild-type mice further demonstrated that the spleen is also important for the survival of B-1a cells. Transfer experiments demonstrate that lack of these cells, as opposed to the absence of the spleen per se, is associated with an inability to mount a rapid immune response against streptococcal polysaccharides. Thus, absence of the spleen and the associated increased susceptibility to streptococcal infections is correlated with lack of B-1a B cells. These findings reveal a hitherto unknown role of the spleen in generating and maintaining the B-1a B cell pool. The Rockefeller University Press 2002-03-18 /pmc/articles/PMC2193734/ /pubmed/11901202 http://dx.doi.org/10.1084/jem.20011140 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Original Article
Wardemann, Hedda
Boehm, Thomas
Dear, Neil
Carsetti, Rita
B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen
title B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen
title_full B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen
title_fullStr B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen
title_full_unstemmed B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen
title_short B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen
title_sort b-1a b cells that link the innate and adaptive immune responses are lacking in the absence of the spleen
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193734/
https://www.ncbi.nlm.nih.gov/pubmed/11901202
http://dx.doi.org/10.1084/jem.20011140
work_keys_str_mv AT wardemannhedda b1abcellsthatlinktheinnateandadaptiveimmuneresponsesarelackingintheabsenceofthespleen
AT boehmthomas b1abcellsthatlinktheinnateandadaptiveimmuneresponsesarelackingintheabsenceofthespleen
AT dearneil b1abcellsthatlinktheinnateandadaptiveimmuneresponsesarelackingintheabsenceofthespleen
AT carsettirita b1abcellsthatlinktheinnateandadaptiveimmuneresponsesarelackingintheabsenceofthespleen