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B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen
Splenectomized individuals are prone to overwhelming infections with encapsulated bacteria and splenectomy of mice increases susceptibility to streptococcal infections, yet the exact mechanism by which the spleen protects against such infections is unknown. Using congenitally asplenic mice as a mode...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193734/ https://www.ncbi.nlm.nih.gov/pubmed/11901202 http://dx.doi.org/10.1084/jem.20011140 |
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author | Wardemann, Hedda Boehm, Thomas Dear, Neil Carsetti, Rita |
author_facet | Wardemann, Hedda Boehm, Thomas Dear, Neil Carsetti, Rita |
author_sort | Wardemann, Hedda |
collection | PubMed |
description | Splenectomized individuals are prone to overwhelming infections with encapsulated bacteria and splenectomy of mice increases susceptibility to streptococcal infections, yet the exact mechanism by which the spleen protects against such infections is unknown. Using congenitally asplenic mice as a model, we show that the spleen is essential for the generation of B-1a cells, a B cell population that cooperates with the innate immune system to control early bacterial and viral growth. Splenectomy of wild-type mice further demonstrated that the spleen is also important for the survival of B-1a cells. Transfer experiments demonstrate that lack of these cells, as opposed to the absence of the spleen per se, is associated with an inability to mount a rapid immune response against streptococcal polysaccharides. Thus, absence of the spleen and the associated increased susceptibility to streptococcal infections is correlated with lack of B-1a B cells. These findings reveal a hitherto unknown role of the spleen in generating and maintaining the B-1a B cell pool. |
format | Text |
id | pubmed-2193734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21937342008-04-14 B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen Wardemann, Hedda Boehm, Thomas Dear, Neil Carsetti, Rita J Exp Med Original Article Splenectomized individuals are prone to overwhelming infections with encapsulated bacteria and splenectomy of mice increases susceptibility to streptococcal infections, yet the exact mechanism by which the spleen protects against such infections is unknown. Using congenitally asplenic mice as a model, we show that the spleen is essential for the generation of B-1a cells, a B cell population that cooperates with the innate immune system to control early bacterial and viral growth. Splenectomy of wild-type mice further demonstrated that the spleen is also important for the survival of B-1a cells. Transfer experiments demonstrate that lack of these cells, as opposed to the absence of the spleen per se, is associated with an inability to mount a rapid immune response against streptococcal polysaccharides. Thus, absence of the spleen and the associated increased susceptibility to streptococcal infections is correlated with lack of B-1a B cells. These findings reveal a hitherto unknown role of the spleen in generating and maintaining the B-1a B cell pool. The Rockefeller University Press 2002-03-18 /pmc/articles/PMC2193734/ /pubmed/11901202 http://dx.doi.org/10.1084/jem.20011140 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Original Article Wardemann, Hedda Boehm, Thomas Dear, Neil Carsetti, Rita B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen |
title | B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen |
title_full | B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen |
title_fullStr | B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen |
title_full_unstemmed | B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen |
title_short | B-1a B Cells that Link the Innate and Adaptive Immune Responses Are Lacking in the Absence of the Spleen |
title_sort | b-1a b cells that link the innate and adaptive immune responses are lacking in the absence of the spleen |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193734/ https://www.ncbi.nlm.nih.gov/pubmed/11901202 http://dx.doi.org/10.1084/jem.20011140 |
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