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Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4

Toll-like receptors (TLRs) and members of the proinflammatory interleukin 1 receptor (IL-1R) family are dependent on the presence of MyD88 for efficient signal transduction. The bipartite nature of MyD88 (N-terminal death domain [DD] and COOH-terminal Toll/IL-1 receptor [TIR] domain) allows it to li...

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Detalles Bibliográficos
Autores principales:	Burns, Kimberly, Janssens, Sophie, Brissoni, Brian, Olivos, Natalia, Beyaert, Rudi, Tschopp, Jürg
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193806/ https://www.ncbi.nlm.nih.gov/pubmed/12538665 http://dx.doi.org/10.1084/jem.20021790

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