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A Single Amino Acid Alteration in Cytoplasmic Domain Determines IL-2 Promoter Activation by Ligation of CD28 but Not Inducible Costimulator (ICOS)

The CD28 family molecules, CD28, and inducible costimulator (ICOS) all provide positive costimulatory signals. However, unlike CD28, ICOS does not costimulate IL-2 secretion. The YMNM motif that exists in the CD28 cytoplasmic domain is a known binding site for phosphatidylinositol 3-kinase (PI3-K) a...

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Detalles Bibliográficos
Autores principales:	Harada, Yohsuke, Ohgai, Daisuke, Watanabe, Ryosuke, Okano, Kazuhiro, Koiwai, Osamu, Tanabe, Kazunari, Toma, Hiroshi, Altman, Amnon, Abe, Ryo
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193818/ https://www.ncbi.nlm.nih.gov/pubmed/12538664 http://dx.doi.org/10.1084/jem.20021305

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