GATA-1 as a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1(low) Mouse Mutant

Here it is shown that the phenotype of adult mice lacking the first enhancer (DNA hypersensitive site I) and the distal promoter of the GATA-1 gene (neoΔHS or GATA-1(low) mutants) reveals defects in mast cell development. These include the presence of morphologically abnormal alcian blue(+) mast cel...

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Detalles Bibliográficos
Autores principales: Migliaccio, Anna Rita, Rana, Rosa Alba, Sanchez, Massimo, Lorenzini, Rodolfo, Centurione, Lucia, Bianchi, Lucia, Vannucchi, Alessandro Maria, Migliaccio, Giovanni, Orkin, Stuart H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193836/
https://www.ncbi.nlm.nih.gov/pubmed/12566412
http://dx.doi.org/10.1084/jem.20021149

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