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The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan

The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the l...

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Detalles Bibliográficos
Autores principales: Chaudhury, Chaity, Mehnaz, Samina, Robinson, John M., Hayton, William L., Pearl, Dennis K., Roopenian, Derry C., Anderson, Clark L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193842/
https://www.ncbi.nlm.nih.gov/pubmed/12566415
http://dx.doi.org/10.1084/jem.20021829
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author Chaudhury, Chaity
Mehnaz, Samina
Robinson, John M.
Hayton, William L.
Pearl, Dennis K.
Roopenian, Derry C.
Anderson, Clark L.
author_facet Chaudhury, Chaity
Mehnaz, Samina
Robinson, John M.
Hayton, William L.
Pearl, Dennis K.
Roopenian, Derry C.
Anderson, Clark L.
author_sort Chaudhury, Chaity
collection PubMed
description The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histocompatibility complex–related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both.
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spelling pubmed-21938422008-04-11 The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan Chaudhury, Chaity Mehnaz, Samina Robinson, John M. Hayton, William L. Pearl, Dennis K. Roopenian, Derry C. Anderson, Clark L. J Exp Med Article The inverse relationship between serum albumin concentration and its half-life suggested to early workers that albumin would be protected from a catabolic fate by a receptor-mediated mechanism much like that proposed for IgG. We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma albumin concentration of FcRn-deficient mice is less than half that of wild-type mice. These results affirm the hypothesis that the major histocompatibility complex–related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both. The Rockefeller University Press 2003-02-03 /pmc/articles/PMC2193842/ /pubmed/12566415 http://dx.doi.org/10.1084/jem.20021829 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Chaudhury, Chaity
Mehnaz, Samina
Robinson, John M.
Hayton, William L.
Pearl, Dennis K.
Roopenian, Derry C.
Anderson, Clark L.
The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan
title The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan
title_full The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan
title_fullStr The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan
title_full_unstemmed The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan
title_short The Major Histocompatibility Complex–related Fc Receptor for IgG (FcRn) Binds Albumin and Prolongs Its Lifespan
title_sort major histocompatibility complex–related fc receptor for igg (fcrn) binds albumin and prolongs its lifespan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193842/
https://www.ncbi.nlm.nih.gov/pubmed/12566415
http://dx.doi.org/10.1084/jem.20021829
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