A Mouse with a Loss-of-function Mutation in the c-Cbl TKB Domain Shows Perturbed Thymocyte Signaling without Enhancing the Activity of the ZAP-70 Tyrosine Kinase

The unique tyrosine kinase binding (TKB) domain of Cbl targets phosphorylated tyrosines on activated protein tyrosine kinases (PTKs); this targeting is considered essential for Cbl proteins to negatively regulate PTKs. Here, a loss-of-function mutation (G304E) in the c-Cbl TKB domain, first identifi...

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Detalles Bibliográficos
Autores principales: Thien, Christine B.F., Scaife, Robin M., Papadimitriou, John M., Murphy, Maria A., Bowtell, David D.L., Langdon, Wallace Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193865/
https://www.ncbi.nlm.nih.gov/pubmed/12591907
http://dx.doi.org/10.1084/jem.20021498

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