Selective Activation of the c-Jun NH(2)-terminal Protein Kinase Signaling Pathway by Stimulatory KIR in the Absence of KARAP/DAP12 in CD4(+) T Cells

Activation of CD4(+) T cells is governed by interplay between stimulatory and inhibitory receptors; predominance of stimulatory signals favors autoimmune reactions. In patients with rheumatoid arthritis, expression of the critical costimulatory molecule, CD28, is frequently lost. Instead, CD4(+)CD28...

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Detalles Bibliográficos
Autores principales: Snyder, Melissa R., Lucas, Mathias, Vivier, Eric, Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193867/
https://www.ncbi.nlm.nih.gov/pubmed/12591902
http://dx.doi.org/10.1084/jem.20020383

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