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Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells
The requirements for survival and self-renewal of peripheral T cells and the nature of mechanisms controlling the size of the naive and memory pool are not completely understood. Here, we examine the involvement of the major histocompatibility complex (MHC) in survival and homeostatic expansion of n...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193871/ https://www.ncbi.nlm.nih.gov/pubmed/12707300 http://dx.doi.org/10.1084/jem.20021812 |
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author | Kassiotis, George Zamoyska, Rose Stockinger, Brigitta |
author_facet | Kassiotis, George Zamoyska, Rose Stockinger, Brigitta |
author_sort | Kassiotis, George |
collection | PubMed |
description | The requirements for survival and self-renewal of peripheral T cells and the nature of mechanisms controlling the size of the naive and memory pool are not completely understood. Here, we examine the involvement of the major histocompatibility complex (MHC) in survival and homeostatic expansion of naive and memory T cells. We show that the homeostatic behavior of naive T cell receptor (TCR)-transgenic T cells can be deduced by the expression levels of TCR and CD5, a negative regulator of TCR signaling. Both these factors determine the strength of TCR stimulation by MHC-derived signals. We further show that, similarly to naive T cells, MHC-derived signals influence the homeostatic expansion capacity of memory T cells under lymphopenic conditions. In contrast to naive T cells, however, memory T cells can reach a homeostatic equilibrium, in which survival/self-renewal of each clone is dissociated from their avidity for MHC-derived signals. |
format | Text |
id | pubmed-2193871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21938712008-04-11 Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells Kassiotis, George Zamoyska, Rose Stockinger, Brigitta J Exp Med Article The requirements for survival and self-renewal of peripheral T cells and the nature of mechanisms controlling the size of the naive and memory pool are not completely understood. Here, we examine the involvement of the major histocompatibility complex (MHC) in survival and homeostatic expansion of naive and memory T cells. We show that the homeostatic behavior of naive T cell receptor (TCR)-transgenic T cells can be deduced by the expression levels of TCR and CD5, a negative regulator of TCR signaling. Both these factors determine the strength of TCR stimulation by MHC-derived signals. We further show that, similarly to naive T cells, MHC-derived signals influence the homeostatic expansion capacity of memory T cells under lymphopenic conditions. In contrast to naive T cells, however, memory T cells can reach a homeostatic equilibrium, in which survival/self-renewal of each clone is dissociated from their avidity for MHC-derived signals. The Rockefeller University Press 2003-04-21 /pmc/articles/PMC2193871/ /pubmed/12707300 http://dx.doi.org/10.1084/jem.20021812 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Kassiotis, George Zamoyska, Rose Stockinger, Brigitta Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells |
title | Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells |
title_full | Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells |
title_fullStr | Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells |
title_full_unstemmed | Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells |
title_short | Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells |
title_sort | involvement of avidity for major histocompatibility complex in homeostasis of naive and memory t cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193871/ https://www.ncbi.nlm.nih.gov/pubmed/12707300 http://dx.doi.org/10.1084/jem.20021812 |
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