CD40 Signaling Is Impaired in L. major–infected Macrophages and Is Rescued by a p38MAPK Activator Establishing a Host-protective Memory T Cell Response

Leishmania, a protozoan parasite, lives and multiplies as amastigote within macrophages. It is proposed that the macrophage expressed CD40 interacts with CD40 ligand on T cells to induce IFN-γ, a Th1-type cytokine that restricts the amastigote growth. Here, we demonstrate that CD40 cross-linking ear...

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Detalles Bibliográficos
Autores principales: Awasthi, Amit, Mathur, Ramkumar, Khan, Aslam, Joshi, Bimba N., Jain, Nitya, Sawant, Sangeeta, Boppana, Ramanamurthy, Mitra, Debashis, Saha, Bhaskar
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193877/
https://www.ncbi.nlm.nih.gov/pubmed/12695487
http://dx.doi.org/10.1084/jem.20022033

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