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DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become sus...

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Detalles Bibliográficos
Autores principales: Tassaneetrithep, Boonrat, Burgess, Timothy H., Granelli-Piperno, Angela, Trumpfheller, Christine, Finke, Jennifer, Sun, Wellington, Eller, Michael A., Pattanapanyasat, Kovit, Sarasombath, Suttipant, Birx, Deborah L., Steinman, Ralph M., Schlesinger, Sarah, Marovich, Mary A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193896/
https://www.ncbi.nlm.nih.gov/pubmed/12682107
http://dx.doi.org/10.1084/jem.20021840
Descripción
Sumario:Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection.