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DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become sus...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193896/ https://www.ncbi.nlm.nih.gov/pubmed/12682107 http://dx.doi.org/10.1084/jem.20021840 |
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author | Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A. |
author_facet | Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A. |
author_sort | Tassaneetrithep, Boonrat |
collection | PubMed |
description | Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection. |
format | Text |
id | pubmed-2193896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21938962008-04-11 DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A. J Exp Med Article Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection. The Rockefeller University Press 2003-04-07 /pmc/articles/PMC2193896/ /pubmed/12682107 http://dx.doi.org/10.1084/jem.20021840 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A. DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells |
title | DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells |
title_full | DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells |
title_fullStr | DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells |
title_full_unstemmed | DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells |
title_short | DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells |
title_sort | dc-sign (cd209) mediates dengue virus infection of human dendritic cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193896/ https://www.ncbi.nlm.nih.gov/pubmed/12682107 http://dx.doi.org/10.1084/jem.20021840 |
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