Cargando…

DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells

Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become sus...

Descripción completa

Detalles Bibliográficos
Autores principales: Tassaneetrithep, Boonrat, Burgess, Timothy H., Granelli-Piperno, Angela, Trumpfheller, Christine, Finke, Jennifer, Sun, Wellington, Eller, Michael A., Pattanapanyasat, Kovit, Sarasombath, Suttipant, Birx, Deborah L., Steinman, Ralph M., Schlesinger, Sarah, Marovich, Mary A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193896/
https://www.ncbi.nlm.nih.gov/pubmed/12682107
http://dx.doi.org/10.1084/jem.20021840
_version_ 1782147577728204800
author Tassaneetrithep, Boonrat
Burgess, Timothy H.
Granelli-Piperno, Angela
Trumpfheller, Christine
Finke, Jennifer
Sun, Wellington
Eller, Michael A.
Pattanapanyasat, Kovit
Sarasombath, Suttipant
Birx, Deborah L.
Steinman, Ralph M.
Schlesinger, Sarah
Marovich, Mary A.
author_facet Tassaneetrithep, Boonrat
Burgess, Timothy H.
Granelli-Piperno, Angela
Trumpfheller, Christine
Finke, Jennifer
Sun, Wellington
Eller, Michael A.
Pattanapanyasat, Kovit
Sarasombath, Suttipant
Birx, Deborah L.
Steinman, Ralph M.
Schlesinger, Sarah
Marovich, Mary A.
author_sort Tassaneetrithep, Boonrat
collection PubMed
description Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection.
format Text
id pubmed-2193896
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21938962008-04-11 DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells Tassaneetrithep, Boonrat Burgess, Timothy H. Granelli-Piperno, Angela Trumpfheller, Christine Finke, Jennifer Sun, Wellington Eller, Michael A. Pattanapanyasat, Kovit Sarasombath, Suttipant Birx, Deborah L. Steinman, Ralph M. Schlesinger, Sarah Marovich, Mary A. J Exp Med Article Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection. The Rockefeller University Press 2003-04-07 /pmc/articles/PMC2193896/ /pubmed/12682107 http://dx.doi.org/10.1084/jem.20021840 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Tassaneetrithep, Boonrat
Burgess, Timothy H.
Granelli-Piperno, Angela
Trumpfheller, Christine
Finke, Jennifer
Sun, Wellington
Eller, Michael A.
Pattanapanyasat, Kovit
Sarasombath, Suttipant
Birx, Deborah L.
Steinman, Ralph M.
Schlesinger, Sarah
Marovich, Mary A.
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_full DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_fullStr DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_full_unstemmed DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_short DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
title_sort dc-sign (cd209) mediates dengue virus infection of human dendritic cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193896/
https://www.ncbi.nlm.nih.gov/pubmed/12682107
http://dx.doi.org/10.1084/jem.20021840
work_keys_str_mv AT tassaneetrithepboonrat dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT burgesstimothyh dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT granellipipernoangela dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT trumpfhellerchristine dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT finkejennifer dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT sunwellington dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT ellermichaela dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT pattanapanyasatkovit dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT sarasombathsuttipant dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT birxdeborahl dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT steinmanralphm dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT schlesingersarah dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells
AT marovichmarya dcsigncd209mediatesdenguevirusinfectionofhumandendriticcells