Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca(2+) Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation

Transforming growth factor (TGF)-β inhibits T cell proliferation and differentiation. TGF-β has been shown to inhibit the expression of transcription factors such as GATA-3 and T-bet that play important roles in T cell differentiation. Here we show that TGF-β inhibits T cell differentiation at a mor...

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Detalles Bibliográficos
Autores principales: Chen, Chang-Hung, Seguin-Devaux, Carole, Burke, Nancy A., Oriss, Timothy B., Watkins, Simon C., Clipstone, Neil, Ray, Anuradha
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193945/
https://www.ncbi.nlm.nih.gov/pubmed/12810687
http://dx.doi.org/10.1084/jem.20021170

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