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B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism
B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies have provided evidence for inhibitory functions of both members via PD-1. Meanwhile, compelling evidence exists for costimulatory function o...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193953/ https://www.ncbi.nlm.nih.gov/pubmed/12810690 http://dx.doi.org/10.1084/jem.20022089 |
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author | Liu, Xingluo Gao, Jian Xin Wen, Jing Yin, Lijie Li, Ou Zuo, Tao Gajewski, Thomas F. Fu, Yang-Xin Zheng, Pan Liu, Yang |
author_facet | Liu, Xingluo Gao, Jian Xin Wen, Jing Yin, Lijie Li, Ou Zuo, Tao Gajewski, Thomas F. Fu, Yang-Xin Zheng, Pan Liu, Yang |
author_sort | Liu, Xingluo |
collection | PubMed |
description | B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies have provided evidence for inhibitory functions of both members via PD-1. Meanwhile, compelling evidence exists for costimulatory function of both members. Here we demonstrate that expression of B7DC on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, B7DC binds to PD-1(−/−) cells and enhances T cell killing in a PD-1–independent mechanism. Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC. |
format | Text |
id | pubmed-2193953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21939532008-04-11 B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism Liu, Xingluo Gao, Jian Xin Wen, Jing Yin, Lijie Li, Ou Zuo, Tao Gajewski, Thomas F. Fu, Yang-Xin Zheng, Pan Liu, Yang J Exp Med Article B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies have provided evidence for inhibitory functions of both members via PD-1. Meanwhile, compelling evidence exists for costimulatory function of both members. Here we demonstrate that expression of B7DC on the tumor cells promotes CD8 T cell–mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, B7DC binds to PD-1(−/−) cells and enhances T cell killing in a PD-1–independent mechanism. Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC. The Rockefeller University Press 2003-06-16 /pmc/articles/PMC2193953/ /pubmed/12810690 http://dx.doi.org/10.1084/jem.20022089 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Liu, Xingluo Gao, Jian Xin Wen, Jing Yin, Lijie Li, Ou Zuo, Tao Gajewski, Thomas F. Fu, Yang-Xin Zheng, Pan Liu, Yang B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism |
title | B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism |
title_full | B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism |
title_fullStr | B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism |
title_full_unstemmed | B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism |
title_short | B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism |
title_sort | b7dc/pdl2 promotes tumor immunity by a pd-1–independent mechanism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193953/ https://www.ncbi.nlm.nih.gov/pubmed/12810690 http://dx.doi.org/10.1084/jem.20022089 |
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