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Expression of a Targeted λ1 Light Chain Gene Is Developmentally Regulated and Independent of Igκ Rearrangements

Immunoglobulin light chain (IgL) rearrangements occur more frequently at Igκ than at Igλ. Previous results suggested that the unrearranged Igκ locus negatively regulates Igλ transcription and/or rearrangement. Here, we demonstrate that expression of a VJλ1-joint inserted into its physiological posit...

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Detalles Bibliográficos
Autores principales:	Oberdoerffer, Philipp, Novobrantseva, Tatiana I., Rajewsky, Klaus
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193966/ https://www.ncbi.nlm.nih.gov/pubmed/12719477 http://dx.doi.org/10.1084/jem.20030402

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