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Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells: Dissociating Proliferation and Development of Effector Function

Activation of naive CD8 T cells to undergo clonal expansion and develop effector function requires three signals: (a) Ag, (b) costimulation, and (c) IL-12 or adjuvant. The requirement for the third signal to stimulate Ag-dependent proliferation is variable, making the greatest contribution when Ag l...

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Detalles Bibliográficos
Autores principales:	Curtsinger, Julie M., Lins, Debra C., Mescher, Matthew F.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193970/ https://www.ncbi.nlm.nih.gov/pubmed/12732656 http://dx.doi.org/10.1084/jem.20021910

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