Molecular Modeling and Functional Mapping of B7-H1 and B7-DC Uncouple Costimulatory Function from PD-1 Interaction

B7-H1 and B7-DC are ligands for PD-1, a receptor implicated in negative regulation of T and B cell functions. These ligands, however, also costimulate T cell responses. It remains elusive whether or not costimulation is mediated through PD-1. By comparative molecular modeling and site-directed mutag...

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Detalles Bibliográficos
Autores principales: Wang, Shengdian, Bajorath, Jürgen, Flies, Dallas B., Dong, Haidong, Honjo, Tasuku, Chen, Lieping
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193977/
https://www.ncbi.nlm.nih.gov/pubmed/12719480
http://dx.doi.org/10.1084/jem.20021752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193977/
https://www.ncbi.nlm.nih.gov/pubmed/12719480
http://dx.doi.org/10.1084/jem.20021752

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