B Cell–specific Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1/OBF.1-deficient Mice

Mice deficient for the transcriptional coactivator BOB.1/OBF.1 show several defects in B cell differentiation. Numbers of immature transitional B cells in the bone marrow are reduced and fewer B cells reach the periphery. Furthermore, germinal center B cells are absent and marginal zone (MZ) B lymph...

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Detalles Bibliográficos
Autores principales: Brunner, Cornelia, Marinkovic, Dragan, Klein, Jörg, Samardzic, Tatjana, Nitschke, Lars, Wirth, Thomas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193979/
https://www.ncbi.nlm.nih.gov/pubmed/12732662
http://dx.doi.org/10.1084/jem.20022014

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