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Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim

By transgenic expression of ovalbumin (OVA) as a model self antigen in the β cells of the pancreas, we have shown that self tolerance can be maintained by the cross-presentation of this antigen on dendritic cells in the draining lymph nodes. Such cross-presentation causes initial activation of OVA-s...

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Detalles Bibliográficos
Autores principales:	Davey, Gayle M., Kurts, Christian, Miller, Jacques F.A.P., Bouillet, Philippe, Strasser, Andreas, Brooks, Andrew G., Carbone, Francis R., Heath, William R.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2002
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194028/ https://www.ncbi.nlm.nih.gov/pubmed/12370256 http://dx.doi.org/10.1084/jem.20020827

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