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Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells

The cytokine potential of developing T helper (Th) cells is directly shaped both positively and negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the recently identified cytokine, interleukin (IL)-21, is preferentially expressed by Th2 cells when compared with...

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Autores principales: Wurster, Andrea L., Rodgers, Vikki L., Satoskar, Abhay R., Whitters, Matthew J., Young, Deborah A., Collins, Mary, Grusby, Michael J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194031/
https://www.ncbi.nlm.nih.gov/pubmed/12370258
http://dx.doi.org/10.1084/jem.20020620
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author Wurster, Andrea L.
Rodgers, Vikki L.
Satoskar, Abhay R.
Whitters, Matthew J.
Young, Deborah A.
Collins, Mary
Grusby, Michael J.
author_facet Wurster, Andrea L.
Rodgers, Vikki L.
Satoskar, Abhay R.
Whitters, Matthew J.
Young, Deborah A.
Collins, Mary
Grusby, Michael J.
author_sort Wurster, Andrea L.
collection PubMed
description The cytokine potential of developing T helper (Th) cells is directly shaped both positively and negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the recently identified cytokine, interleukin (IL)-21, is preferentially expressed by Th2 cells when compared with Th1 cells generated in vitro and in vivo. Exposure of naive Th precursors to IL-21 inhibits interferon (IFN)-γ production from developing Th1 cells. The repression of IFN-γ production is specific in that the expression of other Th1 and Th2 cytokines is unaffected. IL-21 decreases the IL-12 responsiveness of developing Th cells by specifically reducing both signal transducer and activator of transcription 4 protein and mRNA expression. These results suggest that Th2 cell-derived IL-21 regulates the development of IFN-γ–producing Th1 cells which could serve to amplify a Th2 response.
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spelling pubmed-21940312008-04-11 Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells Wurster, Andrea L. Rodgers, Vikki L. Satoskar, Abhay R. Whitters, Matthew J. Young, Deborah A. Collins, Mary Grusby, Michael J. J Exp Med Article The cytokine potential of developing T helper (Th) cells is directly shaped both positively and negatively by the cytokines expressed by the effector Th cell subsets. Here we find that the recently identified cytokine, interleukin (IL)-21, is preferentially expressed by Th2 cells when compared with Th1 cells generated in vitro and in vivo. Exposure of naive Th precursors to IL-21 inhibits interferon (IFN)-γ production from developing Th1 cells. The repression of IFN-γ production is specific in that the expression of other Th1 and Th2 cytokines is unaffected. IL-21 decreases the IL-12 responsiveness of developing Th cells by specifically reducing both signal transducer and activator of transcription 4 protein and mRNA expression. These results suggest that Th2 cell-derived IL-21 regulates the development of IFN-γ–producing Th1 cells which could serve to amplify a Th2 response. The Rockefeller University Press 2002-10-07 /pmc/articles/PMC2194031/ /pubmed/12370258 http://dx.doi.org/10.1084/jem.20020620 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Wurster, Andrea L.
Rodgers, Vikki L.
Satoskar, Abhay R.
Whitters, Matthew J.
Young, Deborah A.
Collins, Mary
Grusby, Michael J.
Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
title Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
title_full Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
title_fullStr Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
title_full_unstemmed Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
title_short Interleukin 21 Is a T Helper (Th) Cell 2 Cytokine that Specifically Inhibits the Differentiation of Naive Th Cells into Interferon γ–producing Th1 Cells
title_sort interleukin 21 is a t helper (th) cell 2 cytokine that specifically inhibits the differentiation of naive th cells into interferon γ–producing th1 cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194031/
https://www.ncbi.nlm.nih.gov/pubmed/12370258
http://dx.doi.org/10.1084/jem.20020620
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