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A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contra...

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Autores principales: Polack, Fernando P., Teng, Michael N., L.Collins, Peter, Prince, Gregory A., Exner, Marcus, Regele, Heinz, Lirman, Dario D., Rabold, Richard, Hoffman, Scott J., Karp, Christopher L., Kleeberger, Steven R., Wills-Karp, Marsha, Karron, Ruth A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194058/
https://www.ncbi.nlm.nih.gov/pubmed/12235218
http://dx.doi.org/10.1084/jem.20020781
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author Polack, Fernando P.
Teng, Michael N.
L.Collins, Peter
Prince, Gregory A.
Exner, Marcus
Regele, Heinz
Lirman, Dario D.
Rabold, Richard
Hoffman, Scott J.
Karp, Christopher L.
Kleeberger, Steven R.
Wills-Karp, Marsha
Karron, Ruth A.
author_facet Polack, Fernando P.
Teng, Michael N.
L.Collins, Peter
Prince, Gregory A.
Exner, Marcus
Regele, Heinz
Lirman, Dario D.
Rabold, Richard
Hoffman, Scott J.
Karp, Christopher L.
Kleeberger, Steven R.
Wills-Karp, Marsha
Karron, Ruth A.
author_sort Polack, Fernando P.
collection PubMed
description Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell–deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.
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spelling pubmed-21940582008-04-11 A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease Polack, Fernando P. Teng, Michael N. L.Collins, Peter Prince, Gregory A. Exner, Marcus Regele, Heinz Lirman, Dario D. Rabold, Richard Hoffman, Scott J. Karp, Christopher L. Kleeberger, Steven R. Wills-Karp, Marsha Karron, Ruth A. J Exp Med Brief Definitive Report Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell–deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease. The Rockefeller University Press 2002-09-16 /pmc/articles/PMC2194058/ /pubmed/12235218 http://dx.doi.org/10.1084/jem.20020781 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Polack, Fernando P.
Teng, Michael N.
L.Collins, Peter
Prince, Gregory A.
Exner, Marcus
Regele, Heinz
Lirman, Dario D.
Rabold, Richard
Hoffman, Scott J.
Karp, Christopher L.
Kleeberger, Steven R.
Wills-Karp, Marsha
Karron, Ruth A.
A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
title A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
title_full A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
title_fullStr A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
title_full_unstemmed A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
title_short A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
title_sort role for immune complexes in enhanced respiratory syncytial virus disease
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194058/
https://www.ncbi.nlm.nih.gov/pubmed/12235218
http://dx.doi.org/10.1084/jem.20020781
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