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A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contra...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194058/ https://www.ncbi.nlm.nih.gov/pubmed/12235218 http://dx.doi.org/10.1084/jem.20020781 |
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author | Polack, Fernando P. Teng, Michael N. L.Collins, Peter Prince, Gregory A. Exner, Marcus Regele, Heinz Lirman, Dario D. Rabold, Richard Hoffman, Scott J. Karp, Christopher L. Kleeberger, Steven R. Wills-Karp, Marsha Karron, Ruth A. |
author_facet | Polack, Fernando P. Teng, Michael N. L.Collins, Peter Prince, Gregory A. Exner, Marcus Regele, Heinz Lirman, Dario D. Rabold, Richard Hoffman, Scott J. Karp, Christopher L. Kleeberger, Steven R. Wills-Karp, Marsha Karron, Ruth A. |
author_sort | Polack, Fernando P. |
collection | PubMed |
description | Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell–deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease. |
format | Text |
id | pubmed-2194058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21940582008-04-11 A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease Polack, Fernando P. Teng, Michael N. L.Collins, Peter Prince, Gregory A. Exner, Marcus Regele, Heinz Lirman, Dario D. Rabold, Richard Hoffman, Scott J. Karp, Christopher L. Kleeberger, Steven R. Wills-Karp, Marsha Karron, Ruth A. J Exp Med Brief Definitive Report Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell–deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease. The Rockefeller University Press 2002-09-16 /pmc/articles/PMC2194058/ /pubmed/12235218 http://dx.doi.org/10.1084/jem.20020781 Text en Copyright © 2002, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Polack, Fernando P. Teng, Michael N. L.Collins, Peter Prince, Gregory A. Exner, Marcus Regele, Heinz Lirman, Dario D. Rabold, Richard Hoffman, Scott J. Karp, Christopher L. Kleeberger, Steven R. Wills-Karp, Marsha Karron, Ruth A. A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease |
title | A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease |
title_full | A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease |
title_fullStr | A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease |
title_full_unstemmed | A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease |
title_short | A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease |
title_sort | role for immune complexes in enhanced respiratory syncytial virus disease |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194058/ https://www.ncbi.nlm.nih.gov/pubmed/12235218 http://dx.doi.org/10.1084/jem.20020781 |
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