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Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo
The failure of CD25(+) regulatory T cells (T(regs)) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use T(regs) expressing a transgenic TCR to show that despite anergy in vitro, T(regs) proliferate in response to immuniza...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194065/ https://www.ncbi.nlm.nih.gov/pubmed/12874258 http://dx.doi.org/10.1084/jem.20030315 |
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author | Walker, Lucy S.K. Chodos, Anna Eggena, Mark Dooms, Hans Abbas, Abul K. |
author_facet | Walker, Lucy S.K. Chodos, Anna Eggena, Mark Dooms, Hans Abbas, Abul K. |
author_sort | Walker, Lucy S.K. |
collection | PubMed |
description | The failure of CD25(+) regulatory T cells (T(regs)) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use T(regs) expressing a transgenic TCR to show that despite anergy in vitro, T(regs) proliferate in response to immunization in vivo. T(regs) also proliferate and accumulate locally in response to transgenically expressed tissue antigen whereas their CD25(−) counterparts are depleted at such sites. Collectively, these data suggest that the anergic state that characterizes CD25(+) T(regs) in vitro may not accurately reflect their responsiveness in vivo. These observations support a model in which T(reg) population dynamics are shaped by the local antigenic environment. |
format | Text |
id | pubmed-2194065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21940652008-04-11 Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo Walker, Lucy S.K. Chodos, Anna Eggena, Mark Dooms, Hans Abbas, Abul K. J Exp Med Article The failure of CD25(+) regulatory T cells (T(regs)) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use T(regs) expressing a transgenic TCR to show that despite anergy in vitro, T(regs) proliferate in response to immunization in vivo. T(regs) also proliferate and accumulate locally in response to transgenically expressed tissue antigen whereas their CD25(−) counterparts are depleted at such sites. Collectively, these data suggest that the anergic state that characterizes CD25(+) T(regs) in vitro may not accurately reflect their responsiveness in vivo. These observations support a model in which T(reg) population dynamics are shaped by the local antigenic environment. The Rockefeller University Press 2003-07-21 /pmc/articles/PMC2194065/ /pubmed/12874258 http://dx.doi.org/10.1084/jem.20030315 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Walker, Lucy S.K. Chodos, Anna Eggena, Mark Dooms, Hans Abbas, Abul K. Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo |
title | Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo |
title_full | Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo |
title_fullStr | Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo |
title_full_unstemmed | Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo |
title_short | Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo |
title_sort | antigen-dependent proliferation of cd4(+) cd25(+) regulatory t cells in vivo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194065/ https://www.ncbi.nlm.nih.gov/pubmed/12874258 http://dx.doi.org/10.1084/jem.20030315 |
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