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Regulation of Cyclooxygenase-2 Expression by the Translational Silencer TIA-1

The cyclooxygenase-2 (COX-2) enzyme catalyzes the rate-limiting step of prostaglandin formation in inflammatory states, and COX-2 overexpression plays a key role in carcinogenesis. To understand the mechanisms regulating COX-2 expression, we examined its posttranscriptional regulation mediated throu...

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Detalles Bibliográficos
Autores principales:	Dixon, Dan A., Balch, Glen C., Kedersha, Nancy, Anderson, Paul, Zimmerman, Guy A., Beauchamp, R. Daniel, Prescott, Stephen M.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194089/ https://www.ncbi.nlm.nih.gov/pubmed/12885872 http://dx.doi.org/10.1084/jem.20030616

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