Cargando…

Normal Thymocyte Negative Selection in TRAIL-deficient Mice

The molecular basis of thymocyte negative selection, which plays a critical role in establishing and maintaining immunological tolerance, is not yet resolved. In particular, the importance of the death receptor subgroup of the tumor necrosis factor (TNF)-family has been the subject of many investiga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cretney, Erika, Uldrich, Adam P., Berzins, Stuart P., Strasser, Andreas, Godfrey, Dale I., Smyth, Mark J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194098/ https://www.ncbi.nlm.nih.gov/pubmed/12900523 http://dx.doi.org/10.1084/jem.20030634

Ejemplares similares

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes
por: Kreslavsky, Taras, et al.
Publicado: (2013)

NKG2D function protects the host from tumor initiation
por: Smyth, Mark J., et al.
Publicado: (2005)

Noncanonical Wnt signaling promotes apoptosis in thymocyte development
por: Liang, Huiling, et al.
Publicado: (2007)

Defined αβ T Cell Receptors with Distinct Ligand Specificities Do Not Require Those Ligands to Signal Double Negative Thymocyte Differentiation
por: Erman, Batu, et al.
Publicado: (2004)

The Functional Basis for Hemophagocytic Lymphohistiocytosis in a Patient with Co-inherited Missense Mutations in the Perforin (PFN1) Gene
por: Voskoboinik, Ilia, et al.
Publicado: (2004)

Thymocytes may persist and differentiate without any input from bone marrow progenitors
por: Peaudecerf, Laetitia, et al.
Publicado: (2012)

Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family
por: Degli-Esposti, Mariapia A., et al.
Publicado: (1997)

T cell receptor engagement by peptide–MHC ligands induces a conformational change in the CD3 complex of thymocytes
por: Gil, Diana, et al.
Publicado: (2005)

Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
por: Maltzman, Jonathan S., et al.
Publicado: (2005)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

Loss of Bim Increases T Cell Production and Function in Interleukin 7 Receptor–deficient Mice
por: Pellegrini, Marc, et al.
Publicado: (2004)

GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1
por: Choi, Seeyoung, et al.
Publicado: (2023)

GENETIC CORRELATION OF A MOUSE LIGHT CHAIN VARIABLE REGION MARKER WITH A THYMOCYTE SURFACE ANTIGEN
por: Gottlieb, Paul D.
Publicado: (1974)

Essential Requirement for C-KIT and Common γ Chain in Thymocyte Development Cannot Be Overruled by Enforced Expression of Bcl-2
por: Rodewald, Hans-Reimer, et al.
Publicado: (2001)

Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma
por: Smyth, Mark J., et al.
Publicado: (2000)

Innate Immune Surveillance of Spontaneous B Cell Lymphomas by Natural Killer Cells and γδ T Cells
por: Street, Shayna E.A., et al.
Publicado: (2004)

Immature Thymocytes Undergoing Receptor Rearrangements Are Resistant to an Atm-Dependent Death Pathway Activated in Mature T Cells by Double-Stranded DNA Breaks
por: Bhandoola, Avinash, et al.
Publicado: (2000)

IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt: Impact on Thymocyte Development
por: Yu, Qing, et al.
Publicado: (2004)

Hepatocyte-specific NEMO deletion promotes NK/NKT cell– and TRAIL-dependent liver damage
por: Beraza, Naiara, et al.
Publicado: (2009)

Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling: Implications for Cancer Therapy
por: Newton, Kim, et al.
Publicado: (2000)

A nonclassical non-Vα14Jα18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance
por: Terabe, Masaki, et al.
Publicado: (2005)

ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4(+)8(+) Thymocytes with Limiting p56(lck)
por: Ashe, Jennifer M., et al.
Publicado: (1999)

Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells
por: Zamai, Loris, et al.
Publicado: (1998)

CD40-deficient, Influenza-specific CD8 Memory T Cells Develop and Function Normally in a CD40-sufficient Environment
por: Lee, Byung O., et al.
Publicado: (2003)

Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells
por: Enders, Anselm, et al.
Publicado: (2003)

Critical Contribution of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) to Apoptosis of Human Cd4(+)T Cells in HIV-1–Infected Hu-Pbl-Nod-Scid Mice
por: Miura, Yoshiharu, et al.
Publicado: (2001)

Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer
por: Enzler, Thomas, et al.
Publicado: (2003)

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis
por: Viny, Aaron D., et al.
Publicado: (2015)

Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
por: Ma, Cindy S., et al.
Publicado: (2008)

P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice
por: Collins, Robert G., et al.
Publicado: (2000)

RESTORATION OF IMMUNE COMPETENCE IN TOLERANT MICE BY PARABIOSIS TO NORMAL MICE
por: Zolla, Susan, et al.
Publicado: (1974)

Impaired Differentiation of Osteoclasts in TREM-2–deficient Individuals
por: Cella, Marina, et al.
Publicado: (2003)

Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells
por: Naik, Edwina, et al.
Publicado: (2011)

A role for GPx3 in activity of normal and leukemia stem cells
por: Herault, Olivier, et al.
Publicado: (2012)

Accelerated tumor growth in mice deficient in DNAM-1 receptor
por: Iguchi-Manaka, Akiko, et al.
Publicado: (2008)

FUCOSIDOSIS: DEFICIENCY OF ALPHA-L-FUCOSIDASE IN CULTURED SKIN FIBROBLASTS
por: Zielke, Klaus, et al.
Publicado: (1972)

Langerhans cells are negative regulators of the anti-Leishmania response
por: Kautz-Neu, Kordula, et al.
Publicado: (2011)

MIXED LYMPHOCYTE REACTIVITY AGAINST NORMAL CELLS BY SPLENIC LYMPHOCYTES FROM TUMOR-BEARING MICE : II. STUDIES OF AUTOIMMUNE-LIKE ACTIVITY IN COMPLETELY SYNGENEIC AND SEMISYNGENEIC SYSTEMS
por: Devlin, R. G., et al.
Publicado: (1974)

Deficiency in Serum Immunoglobulin (Ig)m Predisposes to Development of Igg Autoantibodies
por: Ehrenstein, Michael R., et al.
Publicado: (2000)

Resistance of CD7-deficient Mice to Lipopolysaccharide-induced Shock Syndromes
por: Sempowski, Gregory D., et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_uiil07a8i53gob9tgt7jnht9q2