Cargando…

Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model

The prelude to type-1 diabetes is leukocyte infiltration into the pancreatic islets, or insulitis. This process begins in pancreatic lymph nodes when T lymphocytes reactive to islet β cells encounter antigen-presenting cells (APCs) displaying peptides derived from β cell proteins. We show here that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turley, Shannon, Poirot, Laurent, Hattori, Masakazu, Benoist, Christophe, Mathis, Diane
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194112/ https://www.ncbi.nlm.nih.gov/pubmed/14623908 http://dx.doi.org/10.1084/jem.20030966

Ejemplares similares

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?
por: Benoist, Christophe, et al.
Publicado: (2000)

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33
por: Tuncel, Jonatan, et al.
Publicado: (2019)

CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance
por: Michelson, Daniel A., et al.
Publicado: (2022)

Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells
por: van Santen, Hisse-Martien, et al.
Publicado: (2004)

Developmental and cellular age direct conversion of CD4(+) T cells into RORγ(+) or Helios(+) colon Treg cells
por: Pratama, Alvin, et al.
Publicado: (2019)

The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells
por: Steinman, Ralph M., et al.
Publicado: (2000)

The AKT–mTOR axis regulates de novo differentiation of CD4(+)Foxp3(+) cells
por: Haxhinasto, Sokol, et al.
Publicado: (2008)

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
por: Wong, Jamie, et al.
Publicado: (2007)

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
por: Gray, Daniel, et al.
Publicado: (2007)

C-Reactive Protein Triggers Cell Death in Ischemic Cells
por: Sheriff, Ahmed, et al.
Publicado: (2021)

CD4(+)CD25(+) T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion
por: Herman, Ann E., et al.
Publicado: (2004)

Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraints
por: Nishio, Junko, et al.
Publicado: (2010)

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2
por: Sitrin, Jonathan, et al.
Publicado: (2013)

Major Histocompatibility Complex Class II Molecules Can Protect from Diabetes by Positively Selecting T Cells with Additional Specificities
por: Lühder, Fred, et al.
Publicado: (1998)

Caspase-2-Dependent Dendritic Cell Death, Maturation, and Priming of T Cells in Response to Brucella abortus Infection
por: Li, Xinna, et al.
Publicado: (2012)

Physiology and pathology of T-cell aging
por: Minato, Nagahiro, et al.
Publicado: (2020)

Visualization of CD4/CD8 T Cell Commitment
por: Chan, Susan, et al.
Publicado: (1998)

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response
por: Obst, Reinhard, et al.
Publicado: (2005)

Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
por: Zemmour, David, et al.
Publicado: (2018)

Where CD4(+)CD25(+) T reg cells impinge on autoimmune diabetes
por: Chen, Zhibin, et al.
Publicado: (2005)

PG-Priming Enhances Doxorubicin Influx to Trigger Necrotic and Autophagic Cell Death in Oral Squamous Cell Carcinoma
por: Lin, Shian-Ren, et al.
Publicado: (2018)

Mobilizing Dendritic Cells for Tolerance, Priming, and Chronic Inflammation
por: Sallusto, Federica, et al.
Publicado: (1999)

Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery
por: Das, Riddha, et al.
Publicado: (2023)

Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes
por: Höglund, Petter, et al.
Publicado: (1999)

Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia
por: Váchová, Libuše, et al.
Publicado: (2005)

L-Myc expression by dendritic cells is required for optimal T-cell priming
por: Wumesh, KC, et al.
Publicado: (2014)

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells
por: Van der Borght, Katrien, et al.
Publicado: (2017)

Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs
por: Faulkner, Lee, et al.
Publicado: (2014)

HIV/SIV Infection Primes Monocytes and Dendritic Cells for Apoptosis
por: Laforge, Mireille, et al.
Publicado: (2011)

Ready for Prime Time? Dendritic Cells in High-Grade Gliomas
por: Conarroe, Claire A., et al.
Publicado: (2023)

Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles
por: Connor, Lisa M., et al.
Publicado: (2017)

Alternol triggers immunogenic cell death via reactive oxygen species generation
por: Li, Changlin, et al.
Publicado: (2021)

Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex
por: Blumenthal, Daniel, et al.
Publicado: (2020)

Exploiting the Role of Endogenous Lymphoid-Resident Dendritic Cells in the Priming of NKT Cells and CD8+ T Cells to Dendritic Cell-Based Vaccines
por: Petersen, Troels R., et al.
Publicado: (2011)

In Vitro Priming of Human T Cells by Dendritic Cells Provides a Screening Tool for Candidate Vaccines for Burkholderia pseudomallei
por: Reddi, Durga, et al.
Publicado: (2021)

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo
Publicado: (1993)

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells
por: Fu, Wenxian, et al.
Publicado: (2014)

Activation of dendritic cells by tumor cell death
por: Cirone, Mara, et al.
Publicado: (2012)

Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin
por: Zarin, Payam, et al.
Publicado: (2023)

Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cells
por: Artyomov, Maxim N., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1ut9m6d18nnvc8d8eb992121tv