A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

Although Toll-like receptors (TLRs) are critical mediators of the immune response to pathogens, the influence of polymorphisms in this gene family on human susceptibility to infection is poorly understood. We demonstrated recently that TLR5 recognizes flagellin, a potent inflammatory stimulus presen...

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Detalles Bibliográficos
Autores principales: Hawn, Thomas R., Verbon, Annelies, Lettinga, Kamilla D., Zhao, Lue Ping, Li, Shuying Sue, Laws, Richard J., Skerrett, Shawn J., Beutler, Bruce, Schroeder, Lea, Nachman, Alex, Ozinsky, Adrian, Smith, Kelly D., Aderem, Alan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194120/
https://www.ncbi.nlm.nih.gov/pubmed/14623910
http://dx.doi.org/10.1084/jem.20031220

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