Activation of Microglial Poly(ADP-Ribose)-Polymerase-1 by Cholesterol Breakdown Products during Neuroinflammation: a Link between Demyelination and Neuronal Damage

Multiple sclerosis (MS) is a chronic demyelinating disease in which it has only recently been suggested that damage to neuronal structures plays a key role. Here, we uncovered a link between the release of lipid breakdown products, found in the brain and cerebrospinal fluid (CSF) of MS patients as w...

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Detalles Bibliográficos
Autores principales: Diestel, Antje, Aktas, Orhan, Hackel, Dagmar, Häke, Ines, Meier, Susanne, Raine, Cedric S., Nitsch, Robert, Zipp, Frauke, Ullrich, Oliver
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194134/
https://www.ncbi.nlm.nih.gov/pubmed/14657223
http://dx.doi.org/10.1084/jem.20030975

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