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Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-γ transcriptio...

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Autores principales: Stetson, Daniel B., Mohrs, Markus, Reinhardt, R. Lee, Baron, Jody L., Wang, Zhi-En, Gapin, Laurent, Kronenberg, Mitchell, Locksley, Richard M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194220/
https://www.ncbi.nlm.nih.gov/pubmed/14530376
http://dx.doi.org/10.1084/jem.20030630
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author Stetson, Daniel B.
Mohrs, Markus
Reinhardt, R. Lee
Baron, Jody L.
Wang, Zhi-En
Gapin, Laurent
Kronenberg, Mitchell
Locksley, Richard M.
author_facet Stetson, Daniel B.
Mohrs, Markus
Reinhardt, R. Lee
Baron, Jody L.
Wang, Zhi-En
Gapin, Laurent
Kronenberg, Mitchell
Locksley, Richard M.
author_sort Stetson, Daniel B.
collection PubMed
description Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-γ transcription during thymic development and populate the periphery with both cytokine loci previously modified by histone acetylation. Similarly, NK cells transcribe and modify the IFN-γ gene, but not IL-4, during developmental maturation in the bone marrow. Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes.
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spelling pubmed-21942202008-04-11 Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function Stetson, Daniel B. Mohrs, Markus Reinhardt, R. Lee Baron, Jody L. Wang, Zhi-En Gapin, Laurent Kronenberg, Mitchell Locksley, Richard M. J Exp Med Article Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-γ transcription during thymic development and populate the periphery with both cytokine loci previously modified by histone acetylation. Similarly, NK cells transcribe and modify the IFN-γ gene, but not IL-4, during developmental maturation in the bone marrow. Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes. The Rockefeller University Press 2003-10-06 /pmc/articles/PMC2194220/ /pubmed/14530376 http://dx.doi.org/10.1084/jem.20030630 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Stetson, Daniel B.
Mohrs, Markus
Reinhardt, R. Lee
Baron, Jody L.
Wang, Zhi-En
Gapin, Laurent
Kronenberg, Mitchell
Locksley, Richard M.
Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
title Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
title_full Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
title_fullStr Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
title_full_unstemmed Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
title_short Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
title_sort constitutive cytokine mrnas mark natural killer (nk) and nk t cells poised for rapid effector function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194220/
https://www.ncbi.nlm.nih.gov/pubmed/14530376
http://dx.doi.org/10.1084/jem.20030630
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