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Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-γ transcriptio...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2003
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194220/ https://www.ncbi.nlm.nih.gov/pubmed/14530376 http://dx.doi.org/10.1084/jem.20030630 |
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author | Stetson, Daniel B. Mohrs, Markus Reinhardt, R. Lee Baron, Jody L. Wang, Zhi-En Gapin, Laurent Kronenberg, Mitchell Locksley, Richard M. |
author_facet | Stetson, Daniel B. Mohrs, Markus Reinhardt, R. Lee Baron, Jody L. Wang, Zhi-En Gapin, Laurent Kronenberg, Mitchell Locksley, Richard M. |
author_sort | Stetson, Daniel B. |
collection | PubMed |
description | Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-γ transcription during thymic development and populate the periphery with both cytokine loci previously modified by histone acetylation. Similarly, NK cells transcribe and modify the IFN-γ gene, but not IL-4, during developmental maturation in the bone marrow. Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes. |
format | Text |
id | pubmed-2194220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21942202008-04-11 Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function Stetson, Daniel B. Mohrs, Markus Reinhardt, R. Lee Baron, Jody L. Wang, Zhi-En Gapin, Laurent Kronenberg, Mitchell Locksley, Richard M. J Exp Med Article Natural killer (NK) and NK T cells are tissue lymphocytes that secrete cytokines rapidly upon stimulation. Here, we show that these cells maintain distinct patterns of constitutive cytokine mRNAs. Unlike conventional T cells, NK T cells activate interleukin (IL)-4 and interferon (IFN)-γ transcription during thymic development and populate the periphery with both cytokine loci previously modified by histone acetylation. Similarly, NK cells transcribe and modify the IFN-γ gene, but not IL-4, during developmental maturation in the bone marrow. Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes. The Rockefeller University Press 2003-10-06 /pmc/articles/PMC2194220/ /pubmed/14530376 http://dx.doi.org/10.1084/jem.20030630 Text en Copyright © 2003, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Stetson, Daniel B. Mohrs, Markus Reinhardt, R. Lee Baron, Jody L. Wang, Zhi-En Gapin, Laurent Kronenberg, Mitchell Locksley, Richard M. Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function |
title | Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function |
title_full | Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function |
title_fullStr | Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function |
title_full_unstemmed | Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function |
title_short | Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function |
title_sort | constitutive cytokine mrnas mark natural killer (nk) and nk t cells poised for rapid effector function |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194220/ https://www.ncbi.nlm.nih.gov/pubmed/14530376 http://dx.doi.org/10.1084/jem.20030630 |
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