Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination

Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by activation-induced cytidine deaminase–mediated cytidine deamination of immunoglobulin genes. MutS homologue (Msh) 2(−/−) mice have reduced A-T mutations and CSR. This suggests that Msh2 may play a role in repairing act...

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Detalles Bibliográficos
Autores principales: Martin, Alberto, Li, Ziqiang, Lin, Diana P., Bardwell, Philip D., Iglesias-Ussel, Maria D., Edelmann, Winfried, Scharff, Matthew D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194233/
https://www.ncbi.nlm.nih.gov/pubmed/14568978
http://dx.doi.org/10.1084/jem.20030880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194233/
https://www.ncbi.nlm.nih.gov/pubmed/14568978
http://dx.doi.org/10.1084/jem.20030880

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