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Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination

Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by activation-induced cytidine deaminase–mediated cytidine deamination of immunoglobulin genes. MutS homologue (Msh) 2(−/−) mice have reduced A-T mutations and CSR. This suggests that Msh2 may play a role in repairing act...

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Detalles Bibliográficos
Autores principales:	Martin, Alberto, Li, Ziqiang, Lin, Diana P., Bardwell, Philip D., Iglesias-Ussel, Maria D., Edelmann, Winfried, Scharff, Matthew D.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194233/ https://www.ncbi.nlm.nih.gov/pubmed/14568978 http://dx.doi.org/10.1084/jem.20030880

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