Impaired V(D)J Recombination and Lymphocyte Development in Core RAG1-expressing Mice

RAG1 and RAG2 are the lymphocyte-specific components of the V(D)J recombinase. In vitro analyses of RAG function have relied on soluble, highly truncated “core” RAG proteins. To identify potential functions for noncore regions and assess functionality of core RAG1 in vivo, we generated core RAG1 kno...

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Detalles Bibliográficos
Autores principales: Dudley, Darryll D., Sekiguchi, JoAnn, Zhu, Chengming, Sadofsky, Moshe J., Whitlow, Scott, DeVido, Jeffrey, Monroe, Robert J., Bassing, Craig H., Alt, Frederick W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194253/
https://www.ncbi.nlm.nih.gov/pubmed/14581608
http://dx.doi.org/10.1084/jem.20030627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194253/
https://www.ncbi.nlm.nih.gov/pubmed/14581608
http://dx.doi.org/10.1084/jem.20030627

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