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Two Independent Positive Feedbacks and Bistability in the Bcl-2 Apoptotic Switch
BACKGROUND: The complex interplay between B-cell lymphoma 2 (Bcl-2) family proteins constitutes a crucial checkpoint in apoptosis. Its detailed molecular mechanism remains controversial. Our former modeling studies have selected the ‘Direct Activation Model’ as a better explanation for experimental...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194625/ https://www.ncbi.nlm.nih.gov/pubmed/18213378 http://dx.doi.org/10.1371/journal.pone.0001469 |