Cargando…

Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes

BACKGROUND: Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large an...

Descripción completa

Detalles Bibliográficos
Autores principales: Wiersma, Anje C, Leegwater, Peter AJ, van Oost, Bernard A, Ollier, William E, Dukes-McEwan, Joanna
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194671/
https://www.ncbi.nlm.nih.gov/pubmed/17949487
http://dx.doi.org/10.1186/1746-6148-3-28
_version_ 1782147670239870976
author Wiersma, Anje C
Leegwater, Peter AJ
van Oost, Bernard A
Ollier, William E
Dukes-McEwan, Joanna
author_facet Wiersma, Anje C
Leegwater, Peter AJ
van Oost, Bernard A
Ollier, William E
Dukes-McEwan, Joanna
author_sort Wiersma, Anje C
collection PubMed
description BACKGROUND: Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A number of genes have been identified, which are associated with dilated cardiomyopathy in the human, mouse and hamster. These genes mainly encode structural proteins of the cardiac myocyte. RESULTS: We present the annotation of, and marker development for, 14 of these genes of the dog genome, i.e. α-cardiac actin, caveolin 1, cysteine-rich protein 3, desmin, lamin A/C, LIM-domain binding factor 3, myosin heavy polypeptide 7, phospholamban, sarcoglycan δ, titin cap, α-tropomyosin, troponin I, troponin T and vinculin. A total of 33 Single Nucleotide Polymorphisms were identified for these canine genes and 11 polymorphic microsatellite repeats were developed. CONCLUSION: The presented polymorphisms provide a tool to investigate the role of the corresponding genes in canine Dilated Cardiomyopathy by linkage analysis or association studies.
format Text
id pubmed-2194671
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-21946712008-01-12 Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes Wiersma, Anje C Leegwater, Peter AJ van Oost, Bernard A Ollier, William E Dukes-McEwan, Joanna BMC Vet Res Correspondence BACKGROUND: Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A number of genes have been identified, which are associated with dilated cardiomyopathy in the human, mouse and hamster. These genes mainly encode structural proteins of the cardiac myocyte. RESULTS: We present the annotation of, and marker development for, 14 of these genes of the dog genome, i.e. α-cardiac actin, caveolin 1, cysteine-rich protein 3, desmin, lamin A/C, LIM-domain binding factor 3, myosin heavy polypeptide 7, phospholamban, sarcoglycan δ, titin cap, α-tropomyosin, troponin I, troponin T and vinculin. A total of 33 Single Nucleotide Polymorphisms were identified for these canine genes and 11 polymorphic microsatellite repeats were developed. CONCLUSION: The presented polymorphisms provide a tool to investigate the role of the corresponding genes in canine Dilated Cardiomyopathy by linkage analysis or association studies. BioMed Central 2007-10-19 /pmc/articles/PMC2194671/ /pubmed/17949487 http://dx.doi.org/10.1186/1746-6148-3-28 Text en Copyright © 2007 Wiersma et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Correspondence
Wiersma, Anje C
Leegwater, Peter AJ
van Oost, Bernard A
Ollier, William E
Dukes-McEwan, Joanna
Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
title Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
title_full Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
title_fullStr Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
title_full_unstemmed Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
title_short Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
title_sort canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194671/
https://www.ncbi.nlm.nih.gov/pubmed/17949487
http://dx.doi.org/10.1186/1746-6148-3-28
work_keys_str_mv AT wiersmaanjec caninecandidategenesfordilatedcardiomyopathyannotationofandpolymorphicmarkersfor14genes
AT leegwaterpeteraj caninecandidategenesfordilatedcardiomyopathyannotationofandpolymorphicmarkersfor14genes
AT vanoostbernarda caninecandidategenesfordilatedcardiomyopathyannotationofandpolymorphicmarkersfor14genes
AT ollierwilliame caninecandidategenesfordilatedcardiomyopathyannotationofandpolymorphicmarkersfor14genes
AT dukesmcewanjoanna caninecandidategenesfordilatedcardiomyopathyannotationofandpolymorphicmarkersfor14genes