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Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
BACKGROUND: Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large an...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194671/ https://www.ncbi.nlm.nih.gov/pubmed/17949487 http://dx.doi.org/10.1186/1746-6148-3-28 |
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author | Wiersma, Anje C Leegwater, Peter AJ van Oost, Bernard A Ollier, William E Dukes-McEwan, Joanna |
author_facet | Wiersma, Anje C Leegwater, Peter AJ van Oost, Bernard A Ollier, William E Dukes-McEwan, Joanna |
author_sort | Wiersma, Anje C |
collection | PubMed |
description | BACKGROUND: Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A number of genes have been identified, which are associated with dilated cardiomyopathy in the human, mouse and hamster. These genes mainly encode structural proteins of the cardiac myocyte. RESULTS: We present the annotation of, and marker development for, 14 of these genes of the dog genome, i.e. α-cardiac actin, caveolin 1, cysteine-rich protein 3, desmin, lamin A/C, LIM-domain binding factor 3, myosin heavy polypeptide 7, phospholamban, sarcoglycan δ, titin cap, α-tropomyosin, troponin I, troponin T and vinculin. A total of 33 Single Nucleotide Polymorphisms were identified for these canine genes and 11 polymorphic microsatellite repeats were developed. CONCLUSION: The presented polymorphisms provide a tool to investigate the role of the corresponding genes in canine Dilated Cardiomyopathy by linkage analysis or association studies. |
format | Text |
id | pubmed-2194671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-21946712008-01-12 Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes Wiersma, Anje C Leegwater, Peter AJ van Oost, Bernard A Ollier, William E Dukes-McEwan, Joanna BMC Vet Res Correspondence BACKGROUND: Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A number of genes have been identified, which are associated with dilated cardiomyopathy in the human, mouse and hamster. These genes mainly encode structural proteins of the cardiac myocyte. RESULTS: We present the annotation of, and marker development for, 14 of these genes of the dog genome, i.e. α-cardiac actin, caveolin 1, cysteine-rich protein 3, desmin, lamin A/C, LIM-domain binding factor 3, myosin heavy polypeptide 7, phospholamban, sarcoglycan δ, titin cap, α-tropomyosin, troponin I, troponin T and vinculin. A total of 33 Single Nucleotide Polymorphisms were identified for these canine genes and 11 polymorphic microsatellite repeats were developed. CONCLUSION: The presented polymorphisms provide a tool to investigate the role of the corresponding genes in canine Dilated Cardiomyopathy by linkage analysis or association studies. BioMed Central 2007-10-19 /pmc/articles/PMC2194671/ /pubmed/17949487 http://dx.doi.org/10.1186/1746-6148-3-28 Text en Copyright © 2007 Wiersma et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Correspondence Wiersma, Anje C Leegwater, Peter AJ van Oost, Bernard A Ollier, William E Dukes-McEwan, Joanna Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes |
title | Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes |
title_full | Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes |
title_fullStr | Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes |
title_full_unstemmed | Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes |
title_short | Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes |
title_sort | canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes |
topic | Correspondence |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194671/ https://www.ncbi.nlm.nih.gov/pubmed/17949487 http://dx.doi.org/10.1186/1746-6148-3-28 |
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