Cargando…

Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke

The toll-like receptors (TLRs) are a key component of host defense in the respiratory epithelium. Cigarette smoking is associated with increased susceptibility to infection, while COPD is characterised by bacterial colonisation and infective exacerbations. We found reduced TLR4 gene expression in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	MacRedmond, Ruth E, Greene, Catherine M, Dorscheid, Delbert R, McElvaney, Noel G, O'Neill, Shane J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194695/ https://www.ncbi.nlm.nih.gov/pubmed/18034897 http://dx.doi.org/10.1186/1465-9921-8-84

Ejemplares similares

Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide
por: MacRedmond, Ruth, et al.
Publicado: (2005)

IL-13Rα2/AP-1 complex signalling mediates airway epithelial repair without effects on remodeling pathways
por: Yang, Jasemine S, et al.
Publicado: (2010)

Quantification and Evaluation of the Role of Antielastin Autoantibodies in the Emphysematous Lung
por: Low, Teck Boon, et al.
Publicado: (2011)

Inhibition of Toll-Like Receptor 2-Mediated Interleukin-8 Production in Cystic Fibrosis Airway Epithelial Cells via the α7-Nicotinic Acetylcholine Receptor
por: Greene, Catherine M., et al.
Publicado: (2010)

Fluticasone Induces Epithelial Injury and Alters Barrier Function in Normal Subjects
por: MacRedmond, Ruth E., et al.
Publicado: (2014)

Salmeterol/fluticasone combination in the treatment of COPD
por: Chung, K F
Publicado: (2006)

Antimicrobial proteins and polypeptides in pulmonary innate defence
por: Rogan, Mark P, et al.
Publicado: (2006)

Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique
por: Hassan, Tidi, et al.
Publicado: (2013)

Cost-effectiveness of combination fluticasone propionate–salmeterol 250/50 μg versus salmeterol in severe COPD patients
por: Dalal, Anand A, et al.
Publicado: (2010)

Exploring the views of healthcare professionals on increasing smoking cessation advice for patients
por: Ho, ShuYing, et al.
Publicado: (2013)

Lung involvement at presentation predicts disease activity and permanent organ damage at 6, 12 and 24 months follow - up in ANCA - associated vasculitis
por: Hassan, Tidi M, et al.
Publicado: (2014)

Is There a Therapeutic Role for Selenium in Alpha-1 Antitrypsin Deficiency?
por: Greene, Catherine M., et al.
Publicado: (2013)

Diagnosing α(1)-antitrypsin deficiency: how to improve the current algorithm
por: McElvaney, Noel G.
Publicado: (2015)

Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency
por: McLean, Caitriona, et al.
Publicado: (2009)

MicroRNAs in inflammatory lung disease - master regulators or target practice?
por: Oglesby, Irene K, et al.
Publicado: (2010)

Secretory leucoprotease inhibitor binds to NF-κB binding sites in monocytes and inhibits p65 binding
por: Taggart, Clifford C., et al.
Publicado: (2005)

A survey of the prevalence of smoking and smoking cessation advice received by in patients in two teaching hospitals in Ireland
por: Ohakim, AL, et al.
Publicado: (2015)

Onset of action of indacaterol in patients with COPD: Comparison with salbutamol and salmeterol-fluticasone
por: Balint, Beatrix, et al.
Publicado: (2010)

The role of fluticasone propionate/salmeterol combination therapy in preventing exacerbations of COPD
por: Yawn, Barbara P, et al.
Publicado: (2010)

Extrafine Beclomethasone/formoterol compared to Fluticasone/salmeterol Combination Therapy in COPD
por: Singh, Dave, et al.
Publicado: (2014)

Interleukin-6: obstacles to targeting a complex cytokine in critical illness
por: McElvaney, Oliver J, et al.
Publicado: (2021)

Salmeterol with fluticasone enhances the suppression of IL-8 release and increases the translocation of glucocorticoid receptor by human neutrophils stimulated with cigarette smoke
por: Mortaz, Esmaeil, et al.
Publicado: (2008)

Airway inflammatory markers in individuals with cystic fibrosis and non-cystic fibrosis bronchiectasis
por: Bergin, David A, et al.
Publicado: (2013)

Reply to: “Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality”
por: Franciosi, Alessandro N., et al.
Publicado: (2022)

Reply to Blot et al. and to Inoue et al.
por: McElvaney, Oliver J., et al.
Publicado: (2021)

Tiotropium and Salmeterol in COPD Patients at Risk of Exacerbations: A Post Hoc Analysis from POET-COPD(®)
por: Vogelmeier, Claus F., et al.
Publicado: (2015)

Outcomes in COPD patients receiving tiotropium or salmeterol plus treatment with inhaled corticosteroids
por: Hodder, Richard, et al.
Publicado: (2007)

Role of the fixed combination of fluticasone and salmeterol in adult Chinese patients with asthma and COPD
por: Gao, Jinming, et al.
Publicado: (2015)

Umeclidinium/vilanterol versus fluticasone propionate/salmeterol in COPD: a randomised trial
por: Singh, Dave, et al.
Publicado: (2015)

Understanding the roles of the transcription factors nuclear factor-κB and hypoxia-inducible factor-1α in lung injury
por: Craig, Katherine, et al.
Publicado: (2002)

Safety and efficacy of dual therapy with GSK233705 and salmeterol versus monotherapy with salmeterol, tiotropium, or placebo in a crossover pilot study in partially reversible COPD patients
por: Beier, Jutta, et al.
Publicado: (2012)

Effects of Aging and Smoking Duration on Cigarette Smoke-Induced COPD Severity
por: Kim, Eun-Jung, et al.
Publicado: (2018)

Intracellular Secretory Leukoprotease Inhibitor Modulates Inositol 1,4,5-Triphosphate Generation and Exerts an Anti-Inflammatory Effect on Neutrophils of Individuals with Cystic Fibrosis and Chronic Obstructive Pulmonary Disease
por: Reeves, Emer P., et al.
Publicado: (2013)

Inflammaging increases susceptibility to cigarette smoke-induced COPD
por: John-Schuster, Gerrit, et al.
Publicado: (2015)

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD
por: Fu, Yaw-Syan, et al.
Publicado: (2022)

Alpha-1 antitrypsin augmentation therapy decreases miR-199a-5p, miR-598 and miR-320a expression in monocytes via inhibition of NFκB
por: Hassan, Tidi, et al.
Publicado: (2017)

The bioavailability and airway clearance of the steroid component of budesonide/formoterol and salmeterol/fluticasone after inhaled administration in patients with COPD and healthy subjects: a randomized controlled trial
por: Dalby, Chris, et al.
Publicado: (2009)

Targeting IgG Autoantibodies for Improved Cytotoxicity of Bactericidal Permeability Increasing Protein in Cystic Fibrosis
por: McQuillan, Karen, et al.
Publicado: (2020)

Olodaterol exerts anti-inflammatory effects on COPD airway epithelial cells
por: Yang, Nan, et al.
Publicado: (2021)

Study design considerations in a large COPD trial comparing effects of tiotropium with salmeterol on exacerbations
por: Beeh, Kai-Michael, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_90qnh5at63ablma2lf1fhtjnnr