Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site

BACKGROUND: Ricin is a potent toxin and known bioterrorism threat with no available antidote. The ricin A-chain (RTA) acts enzymatically to cleave a specific adenine base from ribosomal RNA, thereby blocking translation. To understand better the relationship between ligand binding and RTA active sit...

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Detalles Bibliográficos
Autores principales: Carra, John H, McHugh, Colleen A, Mulligan, Sheila, Machiesky, LeeAnn M, Soares, Alexei S, Millard, Charles B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194779/
https://www.ncbi.nlm.nih.gov/pubmed/17986339
http://dx.doi.org/10.1186/1472-6807-7-72

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