Cargando…
TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS
Creatine and trimethylamine oxide (TMAO) are the chief nitrogenous constituents of normal Lophius urine, and both of these organic bases characteristically have high urine/plasma concentration ratios. Competition studies involving various organic bases indicate that creatine and TMAO are excreted in...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1958
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194903/ https://www.ncbi.nlm.nih.gov/pubmed/13587915 |
_version_ | 1782147720309374976 |
---|---|
author | Forster, Roy P. Berglund, Fredrik Rennick, Barbara R. |
author_facet | Forster, Roy P. Berglund, Fredrik Rennick, Barbara R. |
author_sort | Forster, Roy P. |
collection | PubMed |
description | Creatine and trimethylamine oxide (TMAO) are the chief nitrogenous constituents of normal Lophius urine, and both of these organic bases characteristically have high urine/plasma concentration ratios. Competition studies involving various organic bases indicate that creatine and TMAO are excreted independently by separate transport mechanisms. TMAO excretion is inhibited competitively by tetraethylammonium ion (TEA) and by cyanine dye No. 863—compounds previously shown to be transferred actively by an organic base-secreting mechanism of general occurrence among vertebrates. TEA does not inhibit competitively the active tubular reabsorption of TMAO in Squalus with doses which markedly depress its tubular excretion in Lophius. Glycine, which inhibits creatine reabsorption in the dog, does not interfere competitively with its secretion in Lophius. |
format | Text |
id | pubmed-2194903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1958 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21949032008-04-23 TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS Forster, Roy P. Berglund, Fredrik Rennick, Barbara R. J Gen Physiol Article Creatine and trimethylamine oxide (TMAO) are the chief nitrogenous constituents of normal Lophius urine, and both of these organic bases characteristically have high urine/plasma concentration ratios. Competition studies involving various organic bases indicate that creatine and TMAO are excreted independently by separate transport mechanisms. TMAO excretion is inhibited competitively by tetraethylammonium ion (TEA) and by cyanine dye No. 863—compounds previously shown to be transferred actively by an organic base-secreting mechanism of general occurrence among vertebrates. TEA does not inhibit competitively the active tubular reabsorption of TMAO in Squalus with doses which markedly depress its tubular excretion in Lophius. Glycine, which inhibits creatine reabsorption in the dog, does not interfere competitively with its secretion in Lophius. The Rockefeller University Press 1958-11-20 /pmc/articles/PMC2194903/ /pubmed/13587915 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Forster, Roy P. Berglund, Fredrik Rennick, Barbara R. TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS |
title | TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS |
title_full | TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS |
title_fullStr | TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS |
title_full_unstemmed | TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS |
title_short | TUBULAR SECRETION OF CREATINE, TRIMETHYLAMINE OXIDE, AND OTHER ORGANIC BASES BY THE AGLOMERULAR KIDNEY OF LOPHIUS AMERICANUS |
title_sort | tubular secretion of creatine, trimethylamine oxide, and other organic bases by the aglomerular kidney of lophius americanus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194903/ https://www.ncbi.nlm.nih.gov/pubmed/13587915 |
work_keys_str_mv | AT forsterroyp tubularsecretionofcreatinetrimethylamineoxideandotherorganicbasesbytheaglomerularkidneyoflophiusamericanus AT berglundfredrik tubularsecretionofcreatinetrimethylamineoxideandotherorganicbasesbytheaglomerularkidneyoflophiusamericanus AT rennickbarbarar tubularsecretionofcreatinetrimethylamineoxideandotherorganicbasesbytheaglomerularkidneyoflophiusamericanus |