THE INFLUENCE OF HIGH HYDROSTATIC PRESSURE ON COCAINE AND VERATRINE ACTION IN A VERTEBRATE NERVE

The application of high hydrostatic pressure to toad sciatic nerve causes a gain in sodium and a loss of potassium which are not affected by cocaine. However, cocaine action is enhanced by high pressure when counteracting veratrine depolarization and when blocking the action potential. Various effec...

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Detalles Bibliográficos
Autores principales: Gershfeld, Norman L., Shanes, Abraham M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194925/
https://www.ncbi.nlm.nih.gov/pubmed/13620893
Descripción
Sumario:The application of high hydrostatic pressure to toad sciatic nerve causes a gain in sodium and a loss of potassium which are not affected by cocaine. However, cocaine action is enhanced by high pressure when counteracting veratrine depolarization and when blocking the action potential. Various effects of elevated pressure on the after-potentials are presented and the role of ions in these processes is discussed.

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