ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON

Changes in spike configuration and in the inward and outward currents of voltage-clamped axons agree in indicating that the increases in permeability to sodium and potassium ions during activity are depressed by procaine and cocaine and augmented by calcium. At low levels of depolarization, the effe...

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Detalles Bibliográficos
Autores principales: Shanes, A. M., Freygang, W. H., Grundfest, H., Amatniek, E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195003/
https://www.ncbi.nlm.nih.gov/pubmed/13631204
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author Shanes, A. M.
Freygang, W. H.
Grundfest, H.
Amatniek, E.
author_facet Shanes, A. M.
Freygang, W. H.
Grundfest, H.
Amatniek, E.
author_sort Shanes, A. M.
collection PubMed
description Changes in spike configuration and in the inward and outward currents of voltage-clamped axons agree in indicating that the increases in permeability to sodium and potassium ions during activity are depressed by procaine and cocaine and augmented by calcium. At low levels of depolarization, the effect of the multivalent ion is similar to that of the local anesthetics, in keeping with their similar effects on the threshold of excitability. The reduction of membrane conductance at rest requires a higher concentration of the drugs than that needed to affect the increase in permeability with activity.
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spelling pubmed-21950032008-04-23 ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON Shanes, A. M. Freygang, W. H. Grundfest, H. Amatniek, E. J Gen Physiol Article Changes in spike configuration and in the inward and outward currents of voltage-clamped axons agree in indicating that the increases in permeability to sodium and potassium ions during activity are depressed by procaine and cocaine and augmented by calcium. At low levels of depolarization, the effect of the multivalent ion is similar to that of the local anesthetics, in keeping with their similar effects on the threshold of excitability. The reduction of membrane conductance at rest requires a higher concentration of the drugs than that needed to affect the increase in permeability with activity. The Rockefeller University Press 1959-03-20 /pmc/articles/PMC2195003/ /pubmed/13631204 Text en Copyright © Copyright, 1959, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Shanes, A. M.
Freygang, W. H.
Grundfest, H.
Amatniek, E.
ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON
title ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON
title_full ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON
title_fullStr ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON
title_full_unstemmed ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON
title_short ANESTHETIC AND CALCIUM ACTION IN THE VOLTAGE CLAMPED SQUID GIANT AXON
title_sort anesthetic and calcium action in the voltage clamped squid giant axon
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195003/
https://www.ncbi.nlm.nih.gov/pubmed/13631204
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AT freygangwh anestheticandcalciumactioninthevoltageclampedsquidgiantaxon
AT grundfesth anestheticandcalciumactioninthevoltageclampedsquidgiantaxon
AT amatnieke anestheticandcalciumactioninthevoltageclampedsquidgiantaxon

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