Inotropic Effects of Trains of Impulses Applied during the Contraction of Cardiac Muscle

The application of a train of supramaximal stimuli during the absolute refractory period of a cardiac muscle preparation has two effects: a depression of the contraction during which it is applied, and a large potentiation of subsequent contractions. The former is ascribed to a direct effect upon th...

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Detalles Bibliográficos
Autores principales: Brady, A. J., Abbott, B. C., Mommaerts, W. F. H. M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1960
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195089/
https://www.ncbi.nlm.nih.gov/pubmed/19873532
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author Brady, A. J.
Abbott, B. C.
Mommaerts, W. F. H. M.
author_facet Brady, A. J.
Abbott, B. C.
Mommaerts, W. F. H. M.
author_sort Brady, A. J.
collection PubMed
description The application of a train of supramaximal stimuli during the absolute refractory period of a cardiac muscle preparation has two effects: a depression of the contraction during which it is applied, and a large potentiation of subsequent contractions. The former is ascribed to a direct effect upon the cell membrane, and is an indication of the continued control of the contractile event by this membrane. The latter is explained as a sudden liberation of norepinephrine by a stimulation of embedded nerve elements, which norepinephrine then distributes itself through the tissue and finally diffuses away.
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spelling pubmed-21950892008-04-23 Inotropic Effects of Trains of Impulses Applied during the Contraction of Cardiac Muscle Brady, A. J. Abbott, B. C. Mommaerts, W. F. H. M. J Gen Physiol Article The application of a train of supramaximal stimuli during the absolute refractory period of a cardiac muscle preparation has two effects: a depression of the contraction during which it is applied, and a large potentiation of subsequent contractions. The former is ascribed to a direct effect upon the cell membrane, and is an indication of the continued control of the contractile event by this membrane. The latter is explained as a sudden liberation of norepinephrine by a stimulation of embedded nerve elements, which norepinephrine then distributes itself through the tissue and finally diffuses away. The Rockefeller University Press 1960-11-01 /pmc/articles/PMC2195089/ /pubmed/19873532 Text en Copyright © Copyright, 1961, by The Rockefeller Institute This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Brady, A. J.
Abbott, B. C.
Mommaerts, W. F. H. M.
Inotropic Effects of Trains of Impulses Applied during the Contraction of Cardiac Muscle
title Inotropic Effects of Trains of Impulses Applied during the Contraction of Cardiac Muscle
title_full Inotropic Effects of Trains of Impulses Applied during the Contraction of Cardiac Muscle
title_fullStr Inotropic Effects of Trains of Impulses Applied during the Contraction of Cardiac Muscle
title_full_unstemmed Inotropic Effects of Trains of Impulses Applied during the Contraction of Cardiac Muscle
title_short Inotropic Effects of Trains of Impulses Applied during the Contraction of Cardiac Muscle
title_sort inotropic effects of trains of impulses applied during the contraction of cardiac muscle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195089/
https://www.ncbi.nlm.nih.gov/pubmed/19873532
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