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Permeability of Squid Axon Membrane to Various Ions
The permeability of the squid axon membrane was determined by the use of radioisotopes of Na, K, Ca, Cs, and Br. Effluxes of these isotopes were measured mainly by the method of intracellular injection. Measurements of influxes were carried out under continuous intracellular perfusion with an isoton...
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1963
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195293/ https://www.ncbi.nlm.nih.gov/pubmed/13993401 |
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author | Tasaki, Ichiji |
author_facet | Tasaki, Ichiji |
author_sort | Tasaki, Ichiji |
collection | PubMed |
description | The permeability of the squid axon membrane was determined by the use of radioisotopes of Na, K, Ca, Cs, and Br. Effluxes of these isotopes were measured mainly by the method of intracellular injection. Measurements of influxes were carried out under continuous intracellular perfusion with an isotonic solution of potassium sulfate. The Na permeability of the resting (excitable) axonal membrane was found to be roughly equal to the K permeability. The permeability to anion was far smaller than that to cations. It is emphasized that the axonal membrane has properties of a cation exchanger. The physicochemical nature of the "two stable states" of the excitable membrane is discussed on the basis of ion exchange isotherms. |
format | Text |
id | pubmed-2195293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1963 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21952932008-04-23 Permeability of Squid Axon Membrane to Various Ions Tasaki, Ichiji J Gen Physiol Article The permeability of the squid axon membrane was determined by the use of radioisotopes of Na, K, Ca, Cs, and Br. Effluxes of these isotopes were measured mainly by the method of intracellular injection. Measurements of influxes were carried out under continuous intracellular perfusion with an isotonic solution of potassium sulfate. The Na permeability of the resting (excitable) axonal membrane was found to be roughly equal to the K permeability. The permeability to anion was far smaller than that to cations. It is emphasized that the axonal membrane has properties of a cation exchanger. The physicochemical nature of the "two stable states" of the excitable membrane is discussed on the basis of ion exchange isotherms. The Rockefeller University Press 1963-03-01 /pmc/articles/PMC2195293/ /pubmed/13993401 Text en Copyright ©, 1963, by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Tasaki, Ichiji Permeability of Squid Axon Membrane to Various Ions |
title | Permeability of Squid Axon Membrane to Various Ions |
title_full | Permeability of Squid Axon Membrane to Various Ions |
title_fullStr | Permeability of Squid Axon Membrane to Various Ions |
title_full_unstemmed | Permeability of Squid Axon Membrane to Various Ions |
title_short | Permeability of Squid Axon Membrane to Various Ions |
title_sort | permeability of squid axon membrane to various ions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195293/ https://www.ncbi.nlm.nih.gov/pubmed/13993401 |
work_keys_str_mv | AT tasakiichiji permeabilityofsquidaxonmembranetovariousions |