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Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle

Local anesthetics have been found to act as competitive inhibitors of caffeine in frog sartorius muscle. They block caffeine-induced rigor and the attendant increase in Ca(45) influx and efflux. Increased net uptake of sodium, loss of potassium, and concurrent increase in oxygen consumption are all...

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Autor principal: Feinstein, Maurice B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1963
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195324/
https://www.ncbi.nlm.nih.gov/pubmed/14060443
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author Feinstein, Maurice B.
author_facet Feinstein, Maurice B.
author_sort Feinstein, Maurice B.
collection PubMed
description Local anesthetics have been found to act as competitive inhibitors of caffeine in frog sartorius muscle. They block caffeine-induced rigor and the attendant increase in Ca(45) influx and efflux. Increased net uptake of sodium, loss of potassium, and concurrent increase in oxygen consumption are all effectively blocked by procaine. Evidence is presented that the inhibitory effect of the local anesthetics cannot be explained by the formation of molecular complexes with caffeine. Increased efflux of Ca(45) produced by changing from zero calcium Ringer's to 0.1 mM or 1 mM calcium Ringer's is inhibited by procaine and tetracaine. EDTA-stimulated calcium efflux is not affected by either local anesthetic. Caffeine rigor develops in frog muscle depolarized with KCl or rendered electrically inexcitable by sodium lack. Both the rigor and the increased calcium fluxes are inhibited by local anesthetics in depolarized muscle.
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spelling pubmed-21953242008-04-23 Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle Feinstein, Maurice B. J Gen Physiol Article Local anesthetics have been found to act as competitive inhibitors of caffeine in frog sartorius muscle. They block caffeine-induced rigor and the attendant increase in Ca(45) influx and efflux. Increased net uptake of sodium, loss of potassium, and concurrent increase in oxygen consumption are all effectively blocked by procaine. Evidence is presented that the inhibitory effect of the local anesthetics cannot be explained by the formation of molecular complexes with caffeine. Increased efflux of Ca(45) produced by changing from zero calcium Ringer's to 0.1 mM or 1 mM calcium Ringer's is inhibited by procaine and tetracaine. EDTA-stimulated calcium efflux is not affected by either local anesthetic. Caffeine rigor develops in frog muscle depolarized with KCl or rendered electrically inexcitable by sodium lack. Both the rigor and the increased calcium fluxes are inhibited by local anesthetics in depolarized muscle. The Rockefeller University Press 1963-09-01 /pmc/articles/PMC2195324/ /pubmed/14060443 Text en Copyright ©, 1964, by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Feinstein, Maurice B.
Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle
title Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle
title_full Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle
title_fullStr Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle
title_full_unstemmed Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle
title_short Inhibition of Caffeine Rigor and Radiocalcium Movements by Local Anesthetics in Frog Sartorius Muscle
title_sort inhibition of caffeine rigor and radiocalcium movements by local anesthetics in frog sartorius muscle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195324/
https://www.ncbi.nlm.nih.gov/pubmed/14060443
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