Estimation of the Life Span of Red Blood Cells

A modified method for fitting the model of Shemin and Rittenberg to study the life span of red cells is described. In this modification the assumption that incorporation of tag is complete before any cells die is relaxed. A recursion formula useful for fitting the model on the digital computer is gi...

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Detalles Bibliográficos
Autores principales: Carter, Melvin W., Matrone, Gennard, Mendenhall, W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195361/
https://www.ncbi.nlm.nih.gov/pubmed/14155433
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author Carter, Melvin W.
Matrone, Gennard
Mendenhall, W.
author_facet Carter, Melvin W.
Matrone, Gennard
Mendenhall, W.
author_sort Carter, Melvin W.
collection PubMed
description A modified method for fitting the model of Shemin and Rittenberg to study the life span of red cells is described. In this modification the assumption that incorporation of tag is complete before any cells die is relaxed. A recursion formula useful for fitting the model on the digital computer is given. Good results were obtained with data from the sheep, rat, cat, rabbit, and the dog, whereas in several of these cases the method of Shemin and Rittenberg was not satisfactory. By varying critical parameters of the model a continuum of curves is possible. Curves which formerly were explained on the basis of random death can be obtained without this assumption. Limitations and implications of the method are discussed.
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spelling pubmed-21953612008-04-23 Estimation of the Life Span of Red Blood Cells Carter, Melvin W. Matrone, Gennard Mendenhall, W. J Gen Physiol Article A modified method for fitting the model of Shemin and Rittenberg to study the life span of red cells is described. In this modification the assumption that incorporation of tag is complete before any cells die is relaxed. A recursion formula useful for fitting the model on the digital computer is given. Good results were obtained with data from the sheep, rat, cat, rabbit, and the dog, whereas in several of these cases the method of Shemin and Rittenberg was not satisfactory. By varying critical parameters of the model a continuum of curves is possible. Curves which formerly were explained on the basis of random death can be obtained without this assumption. Limitations and implications of the method are discussed. The Rockefeller University Press 1964-05-01 /pmc/articles/PMC2195361/ /pubmed/14155433 Text en Copyright ©, 1964, by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Carter, Melvin W.
Matrone, Gennard
Mendenhall, W.
Estimation of the Life Span of Red Blood Cells
title Estimation of the Life Span of Red Blood Cells
title_full Estimation of the Life Span of Red Blood Cells
title_fullStr Estimation of the Life Span of Red Blood Cells
title_full_unstemmed Estimation of the Life Span of Red Blood Cells
title_short Estimation of the Life Span of Red Blood Cells
title_sort estimation of the life span of red blood cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195361/
https://www.ncbi.nlm.nih.gov/pubmed/14155433
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AT matronegennard estimationofthelifespanofredbloodcells
AT mendenhallw estimationofthelifespanofredbloodcells

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