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The Effects of Several Alcohols on the Properties of the Squid Giant Axon
The effects of several alcohols on the resting potential, action potential, and voltage-clamp currents of the squid giant axon have been measured. All the alcohols employed are similar in that they depress maximum sodium conductance much more than maximum potassium conductance. Octyl alcohol differs...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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The Rockefeller University Press
1964
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195418/ https://www.ncbi.nlm.nih.gov/pubmed/14225257 |
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author | Armstrong, Clay M. Binstock, Leonard |
author_facet | Armstrong, Clay M. Binstock, Leonard |
author_sort | Armstrong, Clay M. |
collection | PubMed |
description | The effects of several alcohols on the resting potential, action potential, and voltage-clamp currents of the squid giant axon have been measured. All the alcohols employed are similar in that they depress maximum sodium conductance much more than maximum potassium conductance. Octyl alcohol differs from the others (C(2) through C(5)) in that it has less tendency to depolarize the axon. Depolarization is always accompanied by a decrease of g (K) near the resting potential, such that the ratio g (K)/g (leak) is decreased. Steady-state inactivation of the sodium ion current is unaffected by alcohols, as is membrane capacity. Resting membrane conductance is usually decreased by alcohols. The findings are discussed in relation to work on monomolecular films. |
format | Text |
id | pubmed-2195418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1964 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21954182008-04-23 The Effects of Several Alcohols on the Properties of the Squid Giant Axon Armstrong, Clay M. Binstock, Leonard J Gen Physiol Article The effects of several alcohols on the resting potential, action potential, and voltage-clamp currents of the squid giant axon have been measured. All the alcohols employed are similar in that they depress maximum sodium conductance much more than maximum potassium conductance. Octyl alcohol differs from the others (C(2) through C(5)) in that it has less tendency to depolarize the axon. Depolarization is always accompanied by a decrease of g (K) near the resting potential, such that the ratio g (K)/g (leak) is decreased. Steady-state inactivation of the sodium ion current is unaffected by alcohols, as is membrane capacity. Resting membrane conductance is usually decreased by alcohols. The findings are discussed in relation to work on monomolecular films. The Rockefeller University Press 1964-11-01 /pmc/articles/PMC2195418/ /pubmed/14225257 Text en Copyright © 1965 by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Armstrong, Clay M. Binstock, Leonard The Effects of Several Alcohols on the Properties of the Squid Giant Axon |
title | The Effects of Several Alcohols on the Properties of the Squid Giant Axon |
title_full | The Effects of Several Alcohols on the Properties of the Squid Giant Axon |
title_fullStr | The Effects of Several Alcohols on the Properties of the Squid Giant Axon |
title_full_unstemmed | The Effects of Several Alcohols on the Properties of the Squid Giant Axon |
title_short | The Effects of Several Alcohols on the Properties of the Squid Giant Axon |
title_sort | effects of several alcohols on the properties of the squid giant axon |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195418/ https://www.ncbi.nlm.nih.gov/pubmed/14225257 |
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