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The Effects of Several Alcohols on the Properties of the Squid Giant Axon

The effects of several alcohols on the resting potential, action potential, and voltage-clamp currents of the squid giant axon have been measured. All the alcohols employed are similar in that they depress maximum sodium conductance much more than maximum potassium conductance. Octyl alcohol differs...

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Detalles Bibliográficos
Autores principales: Armstrong, Clay M., Binstock, Leonard
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1964
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195418/
https://www.ncbi.nlm.nih.gov/pubmed/14225257
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author Armstrong, Clay M.
Binstock, Leonard
author_facet Armstrong, Clay M.
Binstock, Leonard
author_sort Armstrong, Clay M.
collection PubMed
description The effects of several alcohols on the resting potential, action potential, and voltage-clamp currents of the squid giant axon have been measured. All the alcohols employed are similar in that they depress maximum sodium conductance much more than maximum potassium conductance. Octyl alcohol differs from the others (C(2) through C(5)) in that it has less tendency to depolarize the axon. Depolarization is always accompanied by a decrease of g (K) near the resting potential, such that the ratio g (K)/g (leak) is decreased. Steady-state inactivation of the sodium ion current is unaffected by alcohols, as is membrane capacity. Resting membrane conductance is usually decreased by alcohols. The findings are discussed in relation to work on monomolecular films.
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spelling pubmed-21954182008-04-23 The Effects of Several Alcohols on the Properties of the Squid Giant Axon Armstrong, Clay M. Binstock, Leonard J Gen Physiol Article The effects of several alcohols on the resting potential, action potential, and voltage-clamp currents of the squid giant axon have been measured. All the alcohols employed are similar in that they depress maximum sodium conductance much more than maximum potassium conductance. Octyl alcohol differs from the others (C(2) through C(5)) in that it has less tendency to depolarize the axon. Depolarization is always accompanied by a decrease of g (K) near the resting potential, such that the ratio g (K)/g (leak) is decreased. Steady-state inactivation of the sodium ion current is unaffected by alcohols, as is membrane capacity. Resting membrane conductance is usually decreased by alcohols. The findings are discussed in relation to work on monomolecular films. The Rockefeller University Press 1964-11-01 /pmc/articles/PMC2195418/ /pubmed/14225257 Text en Copyright © 1965 by The Rockefeller Institute Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Armstrong, Clay M.
Binstock, Leonard
The Effects of Several Alcohols on the Properties of the Squid Giant Axon
title The Effects of Several Alcohols on the Properties of the Squid Giant Axon
title_full The Effects of Several Alcohols on the Properties of the Squid Giant Axon
title_fullStr The Effects of Several Alcohols on the Properties of the Squid Giant Axon
title_full_unstemmed The Effects of Several Alcohols on the Properties of the Squid Giant Axon
title_short The Effects of Several Alcohols on the Properties of the Squid Giant Axon
title_sort effects of several alcohols on the properties of the squid giant axon
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195418/
https://www.ncbi.nlm.nih.gov/pubmed/14225257
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