Genomewide Expression Analysis in Zebrafish mind bomb Alleles with Pancreas Defects of Different Severity Identifies Putative Notch Responsive Genes

BACKGROUND: Notch signaling is an evolutionarily conserved developmental pathway. Zebrafish mind bomb (mib) mutants carry mutations on mib gene, which encodes a RING E3 ligase required for Notch activation via Delta/Jagged ubiquitylation and internalization. METHODOLOGY/PRINCIPAL FINDINGS: We examin...

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Detalles Bibliográficos
Autores principales: Hegde, Ashok, Qiu, Nick Chuanxin, Qiu, Xuehui, Ho, Steven Hao-Kee, Tay, Kenny Qi-Ye, George, Joshy, Ng, Felicia Soo Lee, Govindarajan, Kunde Ramamoorthy, Gong, Zhiyuan, Mathavan, Sinnakaruppan, Jiang, Yun-Jin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195453/
https://www.ncbi.nlm.nih.gov/pubmed/18213387
http://dx.doi.org/10.1371/journal.pone.0001479

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