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Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25(+)44(−) thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasm...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195557/ https://www.ncbi.nlm.nih.gov/pubmed/10429678 |
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author | Aifantis, Iannis Feinberg, Jacqueline Fehling, Hans Jörg Di Santo, James P. von Boehmer, Harald |
author_facet | Aifantis, Iannis Feinberg, Jacqueline Fehling, Hans Jörg Di Santo, James P. von Boehmer, Harald |
author_sort | Aifantis, Iannis |
collection | PubMed |
description | We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25(+)44(−) thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-β expression can be accounted for by pre-TCR–dependent signal mediation, putting into question the function of a putative pro-TCR. |
format | Text |
id | pubmed-2195557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21955572008-04-16 Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex Aifantis, Iannis Feinberg, Jacqueline Fehling, Hans Jörg Di Santo, James P. von Boehmer, Harald J Exp Med Brief Definitive Report We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25(+)44(−) thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-β expression can be accounted for by pre-TCR–dependent signal mediation, putting into question the function of a putative pro-TCR. The Rockefeller University Press 1999-07-01 /pmc/articles/PMC2195557/ /pubmed/10429678 Text en © 1999 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Aifantis, Iannis Feinberg, Jacqueline Fehling, Hans Jörg Di Santo, James P. von Boehmer, Harald Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex |
title | Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex |
title_full | Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex |
title_fullStr | Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex |
title_full_unstemmed | Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex |
title_short | Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex |
title_sort | early t cell receptor β gene expression is regulated by the pre-t cell receptor–cd3 complex |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195557/ https://www.ncbi.nlm.nih.gov/pubmed/10429678 |
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