Cargando…

Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex

We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25(+)44(−) thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasm...

Descripción completa

Detalles Bibliográficos
Autores principales: Aifantis, Iannis, Feinberg, Jacqueline, Fehling, Hans Jörg, Di Santo, James P., von Boehmer, Harald
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195557/
https://www.ncbi.nlm.nih.gov/pubmed/10429678
_version_ 1782147873020837888
author Aifantis, Iannis
Feinberg, Jacqueline
Fehling, Hans Jörg
Di Santo, James P.
von Boehmer, Harald
author_facet Aifantis, Iannis
Feinberg, Jacqueline
Fehling, Hans Jörg
Di Santo, James P.
von Boehmer, Harald
author_sort Aifantis, Iannis
collection PubMed
description We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25(+)44(−) thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-β expression can be accounted for by pre-TCR–dependent signal mediation, putting into question the function of a putative pro-TCR.
format Text
id pubmed-2195557
institution National Center for Biotechnology Information
language English
publishDate 1999
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21955572008-04-16 Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex Aifantis, Iannis Feinberg, Jacqueline Fehling, Hans Jörg Di Santo, James P. von Boehmer, Harald J Exp Med Brief Definitive Report We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25(+)44(−) thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-β expression can be accounted for by pre-TCR–dependent signal mediation, putting into question the function of a putative pro-TCR. The Rockefeller University Press 1999-07-01 /pmc/articles/PMC2195557/ /pubmed/10429678 Text en © 1999 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Aifantis, Iannis
Feinberg, Jacqueline
Fehling, Hans Jörg
Di Santo, James P.
von Boehmer, Harald
Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
title Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
title_full Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
title_fullStr Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
title_full_unstemmed Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
title_short Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex
title_sort early t cell receptor β gene expression is regulated by the pre-t cell receptor–cd3 complex
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195557/
https://www.ncbi.nlm.nih.gov/pubmed/10429678
work_keys_str_mv AT aifantisiannis earlytcellreceptorbgeneexpressionisregulatedbythepretcellreceptorcd3complex
AT feinbergjacqueline earlytcellreceptorbgeneexpressionisregulatedbythepretcellreceptorcd3complex
AT fehlinghansjorg earlytcellreceptorbgeneexpressionisregulatedbythepretcellreceptorcd3complex
AT disantojamesp earlytcellreceptorbgeneexpressionisregulatedbythepretcellreceptorcd3complex
AT vonboehmerharald earlytcellreceptorbgeneexpressionisregulatedbythepretcellreceptorcd3complex