Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice

Here we provide evidence that the Ikaros family of DNA binding factors is critical for the activity of hemopoietic stem cells (HSCs) in the mouse. Mice homozygous for an Ikaros null mutation display a >30-fold reduction in long-term repopulation units, whereas mice homozygous for an Ikaros domina...

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Detalles Bibliográficos
Autores principales: Nichogiannopoulou, Aliki, Trevisan, Maryanne, Neben, Steve, Friedrich, Christoph, Georgopoulos, Katia
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195677/
https://www.ncbi.nlm.nih.gov/pubmed/10544193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195677/
https://www.ncbi.nlm.nih.gov/pubmed/10544193

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