Nonlymphocyte-Derived Tumor Necrosis Factor Is Required for Induction of Colitis in Recombination Activating Gene (Rag)2(−/−) Mice upon Transfer of Cd4(+)Cd45rb(hi) T Cells

In this study, we addressed the role of tumor necrosis factor (TNF)-α and lymphotoxin (LT)-α in the development of colitis and defined the cellular sources (T cells versus non-T cells) of TNF (TNF-α and LT-α) relevant to disease development. After adoptive transfer of TNF(+/+) CD4(+)CD45RB(hi) splen...

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Detalles Bibliográficos
Autores principales: Corazza, Nadia, Eichenberger, Susanne, Eugster, Hans-Pietro, Mueller, Christoph
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195702/
https://www.ncbi.nlm.nih.gov/pubmed/10562322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195702/
https://www.ncbi.nlm.nih.gov/pubmed/10562322

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