Cargando…

Lineage-Specific Modulation of Interleukin 4 Signaling by Interferon Regulatory Factor 4

Interleukin (IL)-4 is an immunoregulatory cytokine that exerts distinct biological activities on different cell types. Our studies indicate that interferon regulatory factor (IRF)-4 is both a target and a modulator of the IL-4 signaling cascade. IRF-4 expression is strongly upregulated upon costimul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gupta, Sanjay, Jiang, Man, Anthony, Alissa, Pernis, Alessandra B.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1999
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195723/ https://www.ncbi.nlm.nih.gov/pubmed/10601358

Ejemplares similares

Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)
por: Fanzo, Jessica C., et al.
Publicado: (2003)

Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression
por: Rengarajan, Jyothi, et al.
Publicado: (2002)

Effective modulation of CD4(+)CD25(+high) regulatory T and NK cells in malignant patients by combination of interferon-α and interleukin-2
por: Liu, Guangxian, et al.
Publicado: (2012)

IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus
por: Manni, Michela, et al.
Publicado: (2015)

Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells
por: Guo, Zhixiang, et al.
Publicado: (2017)

The adaptor molecule TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating interleukin-2 receptor signaling
por: Yi, Zuoan, et al.
Publicado: (2014)

The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
por: Yi, Woelsung, et al.
Publicado: (2017)

Lineage-specific Requirement for Signal Transducer and Activator of Transcription (Stat)4 in Interferon γ Production from CD4(+) Versus CD8(+) T Cells
por: Carter, Laura L., et al.
Publicado: (1999)

Evolution of lineage-specific functions in ancient cis-regulatory modules
por: Pauls, Stefan, et al.
Publicado: (2015)

Interleukin 2 Signaling Is Required for CD4(+) Regulatory T Cell Function
por: Furtado, Gláucia C., et al.
Publicado: (2002)

Interleukin-4 receptor signaling modulates neuronal network activity
por: Hanuscheck, Nicholas, et al.
Publicado: (2022)

Dual regulation of IRF4 function in T and B cells is required for the coordination of T–B cell interactions and the prevention of autoimmunity
por: Biswas, Partha S., et al.
Publicado: (2012)

Interferon γ Signaling Alters the Function of T Helper Type 1 Cells
por: Tau, Gregory Z., et al.
Publicado: (2000)

Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes: Modulation of Interferon-Regulated Gene Expression by Rel/Nuclear Factor κB
por: Grumont, Raelene J., et al.
Publicado: (2000)

Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma
Publicado: (1995)

Potential Risks Related to Modulating Interleukin-13 and Interleukin-4 Signalling: A Systematic Review
por: Braddock, Martin, et al.
Publicado: (2018)

The Regulatory Effects of Interleukin-4 Receptor Signaling on Neutrophils in Type 2 Immune Responses
por: Egholm, Cecilie, et al.
Publicado: (2019)

Regulatory effect of interleukin-4 and interleukin-13 on colon cancer cell adhesion
por: Kanai, T, et al.
Publicado: (2000)

Simvastatin and ROCK inhibition in Th0 and Th17 systems
por: Isgro, Josephine, et al.
Publicado: (2012)

Interleukin-7 Optimizes FOXP3+CD4+ Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression
por: Simonetta, Federico, et al.
Publicado: (2014)

Interferon regulatory factor 4 attenuates Notch signaling to suppress the development of chronic lymphocytic leukemia
por: Shukla, Vipul, et al.
Publicado: (2016)

Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects
por: Calise, Justine, et al.
Publicado: (2018)

Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus
por: He, Shijun, et al.
Publicado: (2023)

A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages
por: Bamford, Connor G. G., et al.
Publicado: (2018)

Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells
Publicado: (1989)

BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage
por: Tsaytler, Pavel, et al.
Publicado: (2023)

Critical role of intestinal interleukin-4 modulating regulatory T cells for desensitization, tolerance, and inflammation of food allergy
por: Nakajima-Adachi, Haruyo, et al.
Publicado: (2017)

Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice
por: Al Mamun, Abdullah, et al.
Publicado: (2018)

Effects of endogenous inflammation signals elicited by nerve growth factor, interferon-γ, and interleukin-4 on peripheral nerve regeneration
por: Liao, Chien-Fu, et al.
Publicado: (2019)

Modulation of Human Immunodeficiency Virus 1 Replication by Interferon Regulatory Factors
por: Sgarbanti, Marco, et al.
Publicado: (2002)

Modulation of mice immune responses against Schistosoma mansoni infection with anti-schistosomiasis drugs: Role of interleukin-4 and interferon-gamma
por: Sharaf, Osama F., et al.
Publicado: (2022)

Genetic and epigenetic variation in the lineage specification of regulatory T cells
por: Arvey, Aaron, et al.
Publicado: (2015)

Killer-cell inhibitory receptors, CD158a/b, are upregulated by interleukin-2, but not interferon-gamma or interleukin-4.
por: Kogure, T, et al.
Publicado: (1999)

Role of interleukin 2, interleukin 4, and alpha, beta, and gamma interferon in stimulating macrophage antibody-dependent tumoricidal activity
Publicado: (1988)

Macrophage activation by lipopolysaccharide, interferon-γ and interleukin-4: effect of fatty acid metabolism
por: Darmani, H., et al.
Publicado: (1995)

Regulatory Role of T Cells Producing both Interferon γ and Interleukin 10 in Persistent Infection
por: Trinchieri, Giorgio
Publicado: (2001)

Hypothermia Protects Mice Against Ischemic Stroke by Modulating Macrophage Polarization Through Upregulation of Interferon Regulatory Factor-4
por: Yu, Xinyuan, et al.
Publicado: (2021)

Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells
por: Yang, Wei-Cheng, et al.
Publicado: (2017)

Interferon regulatory factor 4 (IRF4) is overexpressed in human non-small cell lung cancer (NSCLC) and activates the Notch signaling pathway
por: Qian, Yajuan, et al.
Publicado: (2017)

Enhanced TCR-induced Apoptosis in Interferon Regulatory Factor 4–deficient CD4(+) Th Cells
por: Lohoff, Michael, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_evv7tpjoaum6misdn5slv9jhh9