High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia

To assess the potency of low-affinity anti–red blood cell (RBC) autoantibodies in the induction of anemia, we generated an immunoglobulin (Ig)G2a class-switch variant of a 4C8 IgM anti–mouse RBC autoantibody, and compared its pathogenic potential with that of its IgM isotype and a high-affinity 34-3...

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Detalles Bibliográficos
Autores principales: Fossati-Jimack, Liliane, Reininger, Luc, Chicheportiche, Yves, Clynes, Raphael, Ravetch, Jeffrey V., Honjo, Tasuku, Izui, Shozo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195740/
https://www.ncbi.nlm.nih.gov/pubmed/10587359

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