Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40

CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK i...

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Detalles Bibliográficos
Autores principales: Garceau, Norman, Kosaka, Yoko, Masters, Sally, Hambor, John, Shinkura, Reiko, Honjo, Tasuku, Noelle, Randolph J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195761/
https://www.ncbi.nlm.nih.gov/pubmed/10637282
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author Garceau, Norman
Kosaka, Yoko
Masters, Sally
Hambor, John
Shinkura, Reiko
Honjo, Tasuku
Noelle, Randolph J.
author_facet Garceau, Norman
Kosaka, Yoko
Masters, Sally
Hambor, John
Shinkura, Reiko
Honjo, Tasuku
Noelle, Randolph J.
author_sort Garceau, Norman
collection PubMed
description CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-κB activation via CD40.
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spelling pubmed-21957612008-04-16 Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40 Garceau, Norman Kosaka, Yoko Masters, Sally Hambor, John Shinkura, Reiko Honjo, Tasuku Noelle, Randolph J. J Exp Med Brief Definitive Report CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor κB (NF-κB)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-κB activation via CD40. The Rockefeller University Press 2000-01-17 /pmc/articles/PMC2195761/ /pubmed/10637282 Text en © 2000 The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Garceau, Norman
Kosaka, Yoko
Masters, Sally
Hambor, John
Shinkura, Reiko
Honjo, Tasuku
Noelle, Randolph J.
Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
title Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
title_full Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
title_fullStr Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
title_full_unstemmed Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
title_short Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40
title_sort lineage-restricted function of nuclear factor κb–inducing kinase (nik) in transducing signals via cd40
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2195761/
https://www.ncbi.nlm.nih.gov/pubmed/10637282
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